Assessment of myocardial injury after reperfused infarction by T1ρ cardiovascular magnetic resonance
Assessment of myocardial injury after reperfused infarction by T1ρ cardiovascular magnetic resonance
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DOI：
10.1186/s12968-017-0332-z
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发表时间：
2017-02-15
影响因子：
6.4
通讯作者：
Witschey, Walter R. T.
中科院分区：
文献类型：
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作者：
Stoffers, Rutger H.;Madden, Marie;Witschey, Walter R. T.
背景：T1Rho和其他内源性造影剂(T2、T1)在再灌流心肌梗死(MI)后1个月的变化尚不确定。我们进行了一项猪再灌流心肌梗死的研究，连续监测MI后1周和4周的T1 Rho、T2和T1松弛、瘢痕大小和跨壁情况。方法：10只约克夏猪阻断旋支动脉90min再灌注。分别于1周(n=10)和4周(n=5)采集T1Rho、T2和自然T1MAP和晚期Gd增强(LGE)心血管磁共振(CMR)数据。半自动FWHM(全宽半高)阈值用于评估瘢痕大小和透壁性，并与组织学进行比较。比较1周和4周时健康心肌和远隔心肌的松弛时间和对比噪声比。结果：心肌梗死后1周和4周，T1分别为421.3+/-108.8和480.0+/-33.2ms，Delta T1Rho分别为68.1+/-11.6和74.3+/-14.2ms，Delta T2分别为51.0+/-10.1和59.2±11.4ms。对比噪声比CNRT1=7.0+/-3.5(1周)和6.9+/-2.4(4周)，CNRT1 Rho=12.0+/-6.2和12.3+/-3.2，CNRT2=8.0+/-3.6和10.3+/-5.8。与LGE相比，T1、Rho、T1和T2组的梗塞面积无显著差异(p=0.14)，1~4周的梗塞面积显著减小(p<；0.01)。心肌梗死后1~4周，单个心肌梗死面积变化为Delta T1Rho=-3.8%，Delta T1=-3.5%，Delta Lge=-2.8%，而T2心肌梗死面积无明显变化。结论：T1Rho与心肌梗死后1周和4周的左心室病理改变高度相关，是一种有用的内源性心肌声学造影方法。
Background: The evolution of T1 rho and of other endogenous contrast methods (T2, T1) in the first month after reperfused myocardial infarction (MI) is uncertain. We conducted a study of reperfused MI in pigs to serially monitor T1 rho, T2 and T1 relaxation, scar size and transmurality at 1 and 4 weeks post-MI.Methods: Ten Yorkshire swine underwent 90 min of occlusion of the circumflex artery and reperfusion. T1 rho, T2 and native T1 maps and late gadolinium enhanced (LGE) cardiovascular magnetic resonance (CMR) data were collected at 1 week (n = 10) and 4 weeks (n = 5). Semi-automatic FWHM (full width half maximum) thresholding was used to assess scar size and transmurality and compared to histology. Relaxation times and contrast-to-noise ratio were compared in healthy and remote myocardium at 1 and 4 weeks. Linear regression and Bland-Altman was performed to compare infarct size and transmurality.Results: Relaxation time differences between infarcted and remote myocardial tissue were.T1 (infarct-remote) = 421.3 +/- 108.8 (1 week) and 480.0 +/- 33.2 ms (4 week), Delta T1 rho = 68.1 +/- 11.6 and 74.3 +/- 14.2, and Delta T2 = 51.0 +/- 10.1 and 59.2 +/- 11.4 ms. Contrast-to-noise ratio was CNRT1 = 7.0 +/- 3.5 (1 week) and 6.9 +/- 2.4 (4 week), CNRT1 rho = 12.0 +/- 6.2 and 12.3 +/- 3.2, and CNRT2 = 8.0 +/- 3.6 and 10.3 +/- 5.8. Infarct size was not significantly different for T1 rho, T1 and T2 compared to LGE (p = 0.14) and significantly decreased from 1 to 4 weeks (p < 0.01). Individual infarct size changes were Delta T1 rho = -3.8%, Delta T1 = -3.5% and Delta LGE = -2.8% from 1 -4 weeks, but there was no observed change in infarct size for T2 or histologically.Conclusions: T1 rho was highly correlated with alterations left ventricle (LV) pathology at 1 and 4 weeks post-MI and therefore it may be a useful method endogenous contrast imaging of infarction.