Inflammation and wound healing: the role of bacteria in the immuno-regulation of wound healing.
Inflammation and wound healing: the role of bacteria in the immuno-regulation of wound healing.
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DOI：
10.1177/1534734604271810
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发表时间：
2004-12-01
期刊：
影响因子：
--
通讯作者：
Thomas, David W
中科院分区：
文献类型：
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作者：
Jones, Stuart G;Edwards, Ruth;Thomas, David W
伤口愈合是一系列复杂的事件，其中的不平衡可能导致伤口无法愈合，对患者和卫生保健服务都有重大影响。尽管这些事件背后的确切机制尚不完全清楚，但炎症过程和先天免疫系统不仅在正常伤口愈合中起着至关重要的作用，而且在延迟伤口愈合的病理生理学中也起着至关重要的作用。这些防御机制受到潜在疾病状态和医疗条件的影响，例如糖尿病、静脉功能不全和与急性创伤相关的炎症。然而，重要的是，这些过程在健康情况下也会受到伤口内细菌的调节。本文探讨了炎症介质在伤口愈合过程中的作用，并讨论了这些介质在正常愈合失败时的功能。讨论了伤口对细菌污染的反应以及细菌对伤口愈合的影响。
Wound healing is a sequence of complex events, an imbalance of which can result in a failure of the wound to heal, with significant implications for patients and health care services alike. Although the exact mechanism that underlies these events is not fully understood, inflammatory processes and the innate immune system play a vital role, not only in normal wound healing but also in the pathophysiology of delayed wound healing. These defense mechanisms are affected by underlying disease states and medical conditions, for example, diabetes, venous insufficiency, and the inflammation associated with acute trauma. Importantly, however, these processes are also modulated in health by bacteria within the wound. This article examines the role of the mediators of inflammation involved in the wound-healing process and discusses the function of these mediators when normal healing fails. The reaction of the wound to bacterial contamination and the effect of bacteria on wound healing are also discussed.