Convergence of forepaw somatosensory and motor cortical projections in the striatum, claustrum, thalamus, and pontine nuclei of cats.
Convergence of forepaw somatosensory and motor cortical projections in the striatum, claustrum, thalamus, and pontine nuclei of cats.
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猫纹状体、屏状核、丘脑和脑桥核中前爪体感和运动皮质投射的汇聚。
DOI：
10.1007/s00429-021-02405-6
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发表时间：
2022
影响因子：
3.1
通讯作者：
Alloway,KevinD
中科院分区：
文献类型：
--
作者：
Smith,JaredB;Chakrabarti,Shubhodeep;Mowery,ToddM;Alloway,KevinD
基底神经节和脑桥小脑系统调节躯体感觉引导的运动行为，并接受来自感觉运动皮层的重要输入。此外，屏状核和丘脑是前脑皮层下结构，与躯体感觉和运动皮层有联系。我们以前在大鼠的研究表明，初级和次级躯体感觉皮层（S1和S2）发送重叠的投射到新纹状体和脑桥核，而初级运动皮层（M1和S1）的重叠要弱得多。此外，我们已经表明，M1，而不是S1，项目的屏状体在大鼠。目前研究的目的是将这些啮齿动物的投射模式与猫的连接进行比较，猫是一种在单独的系统发育总目中进化的哺乳动物物种。将三种不同的顺行示踪剂注射到猫的M1、S1和S2的生理学鉴定的前爪代表中。标记的纤维终止于同侧纹状体（尾状核和壳核），屏状核，丘脑和脑桥核。示踪剂标记的数字重建使我们能够量化每个皮层下区域的标记的归一化分布，以及示踪剂重叠的量。令人惊讶的是，与我们以前在啮齿动物中的发现相反，我们观察到M1和S1投射在纹状体和脑桥中显著会聚，而S1和S2重叠要弱得多。此外，而大鼠S1不项目，以屏状体，我们证实了密集的屏状输入从S1在猫。这些结果表明，大鼠和猫的基底神经节，屏状核和脑桥小脑系统已经进化出不同的感觉运动皮层会聚模式。
The basal ganglia and pontocerebellar systems regulate somesthetic-guided motor behaviors and receive prominent inputs from sensorimotor cortex. In addition, the claustrum and thalamus are forebrain subcortical structures that have connections with somatosensory and motor cortices. Our previous studies in rats have shown that primary and secondary somatosensory cortex (S1 and S2) send overlapping projections to the neostriatum and pontine nuclei, whereas, overlap of primary motor cortex (M1) and S1 was much weaker. In addition, we have shown that M1, but not S1, projects to the claustrum in rats. The goal of the current study was to compare these rodent projection patterns with connections in cats, a mammalian species that evolved in a separate phylogenetic superorder. Three different anterograde tracers were injected into the physiologically identified forepaw representations of M1, S1, and S2 in cats. Labeled fibers terminated throughout the ipsilateral striatum (caudate and putamen), claustrum, thalamus, and pontine nuclei. Digital reconstructions of tracer labeling allowed us to quantify both the normalized distribution of labeling in each subcortical area from each tracer injection, as well as the amount of tracer overlap. Surprisingly, in contrast to our previous findings in rodents, we observed M1 and S1 projections converging prominently in striatum and pons, whereas, S1 and S2 overlap was much weaker. Furthermore, whereas, rat S1 does not project to claustrum, we confirmed dense claustral inputs from S1 in cats. These findings suggest that the basal ganglia, claustrum, and pontocerebellar systems in rat and cat have evolved distinct patterns of sensorimotor cortical convergence.
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