Expeditious Metal-Free Access to Functionalized Polycyclic Acetals under Mild Aqueous Conditions
Expeditious Metal-Free Access to Functionalized Polycyclic Acetals under Mild Aqueous Conditions
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DOI：
10.1021/ol501986f
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发表时间：
2014-08-15
期刊：
影响因子：
5.2
通讯作者：
Ramasastry, S. S. V.
中科院分区：
文献类型：
--
作者：
Kasare, Sanghratna;Bankar, Siddheshwar K.;Ramasastry, S. S. V.
介绍了一种在温和的水相条件下合成呋喃并呋喃和双环双缩醛的简便方法。这种潜在的绿色、面向多样性的方法包括级联Michael加成和吡喃酮和1，3-二羰基的环缩合反应。根据所使用的吡喃酮的类型，在产品类别中观察到了一个有趣的转变。本文获得的第一类和第二类产品是几种具有生物活性的天然产物和具有药用价值的化合物的组成部分。
A facile approach for the synthesis of furopyrans and bicyclic bisacetals under mild aqueous conditions is described. This potentially green, diversity oriented approach involves cascade Michael addition and cycloacetalization of pyranones and 1,3-dicarbonyls. An interesting switch in the product class was observed depending on the type of pyranone employed. Products of type I and II obtained herein are an integral part of several bioactive natural products and medicinally interesting compounds.