Surface structure and in vitro apatite-forming ability of titanium doped with various metals
Surface structure and in vitro apatite-forming ability of titanium doped with various metals
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DOI：
10.1016/j.colsurfa.2018.07.027
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发表时间：
2018-10-20
影响因子：
5.2
通讯作者：
Kanetaka, Hiroyasu
中科院分区：
文献类型：
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作者：
Kawashita, Masakazu;Iwabuchi, Yuta;Kanetaka, Hiroyasu
通过氢氧化钠（NaOH）表面改性和随后的热处理，可以使钛及其合金在模拟体液（SBF）中具有磷灰石形成能力，在日本被临床用于钛合金髋关节的治疗。然而，对于钛中金属的掺入量和化学状态与SBF中磷灰石形成能力之间的关系，目前还没有系统的研究。本文中，我们用含有不同类型（铝、钙、铬、铜、锌和银）和金属离子浓度（0.01、0.1和1m）的水溶液处理氢氧化钠修饰的钛，研究了这种关系。结果表明，锐钛矿的形成和加入钛中的金属的化学状态控制着磷灰石的形成能力。此外，金属的化学状态可以用电离趋势来解释。这些发现将有助于未来设计用于骨科或牙科植入物的金属掺杂生物活性钛。
Surface modification by sodium hydroxide (NaOH) and subsequent heat treatment can provide titanium and its alloys an apatite-forming ability in simulated body fluid (SBF), and is used clinically to treat titanium alloy hip joints in Japan. However, there is no systematic study on the relationship between the amount and chemical state of metals incorporated into titanium and the apatite-forming ability in SBF. We have studied this relationship herein by treating NaOH-modified titanium with aqueous solutions containing different types (aluminum, calcium, chromium, copper, zinc, and silver) and concentrations (0.01, 0.1, and 1 M) of metal ions. As a result, we found that formation of anatase and the chemical states of the metals incorporated into titanium control the apatite-forming ability. Further, the chemical states of the metals can be interpreted in terms of the ionization tendency. These findings would aid future design of metal-doped bioactive titanium for orthopedic or dental implants.