Detection of К-Opioid Receptor mRNA in Immature T Cells

Detection of К-Opioid Receptor mRNA in Immature T Cells
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未成熟 T 细胞中 К-阿片受体 mRNA 的检测

DOI:
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发表时间:
1995
期刊:
影响因子:
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通讯作者:
T. Rogers
T. Rogers
中科院分区:
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文献类型:
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作者:
S. Belkowski;Jinmin Zhu;L. Liu;T. Eisenstein;M. Adler;T. Rogers

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阿片受体首先在神经系统细胞上检测到(1,2)。使用放射性标记的配体,从免疫系统细胞发育的细胞系已显示表达κ阿片受体(3,4)。一个例子是从C58/J小鼠发展的R1.1 T-胸腺瘤。该细胞系已被证明表达表面标志物Thy 1.2和H-2 k(5)。通过受体结合试验,该细胞系也显示表达κ受体(4)。关于这种T细胞系的分化阶段或功能能力知之甚少。
Opioid receptors were first detected on the cells of the nervous system (1,2). Using radiolabeled ligands, cell lines developed from cells of the immune system have been shown to express the kappa opiate receptor (3,4). One example is the R1.1 T-thymoma developed from a C58/J mouse. This cell line has been shown to express the surface markers Thy 1.2 and H-2 k(5). This cell line has also been shown to express the kappa receptor by receptor binding assays (4). Little is known about the differentiation stage or functional capacity of this T cell line.
DOI: 10.1172/jci113140
发表时间: 1987-09
期刊: The Journal of clinical investigation
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