Assessment of quantitative magnetic resonance imaging metrics in the brain through the use of a novel phantom.
Assessment of quantitative magnetic resonance imaging metrics in the brain through the use of a novel phantom.
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通过使用新型模型来评估大脑中的定量磁共振成像指标。
DOI：
10.1080/02699052.2018.1494855
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发表时间：
2018
期刊：
影响因子：
1.9
通讯作者：
Schneider,Walter
中科院分区：
文献类型：
--
作者：
Wilde,ElisabethA;Provenzale,JamesM;Taylor,BrianA;Boss,Michael;Zuccolotto,Anthony;Hachey,Rebecca;Pathak,Sudhir;Tate,DavidF;Abildskov,TracyJ;Schneider,Walter
目的：利用弥散张量成像(DTI)和其他成像手段，对多部位和纵向神经影像研究在揭示颅脑损伤(TBI)和脑震荡后的恢复和神经退行性变的轨迹方面具有重要意义。这项研究使用一个人体和一个结合神经创伤合剂慢性效应开发的新型体模，评估了四种扫描仪测量各向异性扩散的差异。方法：人体扫描提供生物组织内的测量，而新的物理体模提供各向异性管内扩散的测量作为轴突内水扩散的模型。比较扫描仪内和扫描仪间的测量差异，并计算其对效应大小的影响。结果：扫描仪内重测分数各向异性(FA)的可靠性估计在测试间隔内相对稳定。人体组织和体模显示出相似的FA范围、高的线性度和较大的装置内效应尺寸。然而，FA的扫描仪间测量结果有显著差异，其中一些超过了轻度脑损伤的典型DTI效应大小。结论：弥散体模可用于更好地阐明基于DTI的测量中扫描仪间的变异性，并为更好地校准多点和纵向研究中使用的扫描仪所获得的结果提供了机会。正在评估新的解决方案，以了解并有可能克服这些差异。
Objective: Multisite and longitudinal neuroimaging studies are important in uncovering trajectories of recovery and neurodegeneration following traumatic brain injury (TBI) and concussion through the use of diffusion tensor imaging (DTI) and other imaging modalities. This study assessed differences in anisotropic diffusion measurement across four scanners using a human and a novel phantom developed in conjunction with the Chronic Effects of Neurotrauma Consortium.Method: Human scans provided measurement within biological tissue, and the novel physical phantom provided measures of anisotropic intra-tubular diffusion to serve as a model for intra-axonal water diffusion. Intra- and inter-scanner measurement variances were compared, and the impact on effect size was calculated.Results: Intra-scanner test–retest reliability estimates for fractional anisotropy (FA) demonstrated relative stability over testing intervals. The human tissue and phantom showed similar FA ranges, high linearity and large within-device effect sizes. However, inter-scanner measures of FA indicated substantial differences, some of which exceeded typical DTI effect sizes in mild TBI.Conclusion: The diffusion phantom may be used to better elucidate inter-scanner variability in DTI-based measurement and provides an opportunity to better calibrate results obtained from scanners used in multisite and longitudinal studies. Novel solutions are being evaluated to understand and potentially overcome these differences.