How Does Obesity Drive Human Carcinogenesis? Challenges in Dissecting the Mechanisms of Adipose-Epithelial Signaling.
How Does Obesity Drive Human Carcinogenesis? Challenges in Dissecting the Mechanisms of Adipose-Epithelial Signaling.
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肥胖如何导致人类致癌？
DOI：
10.1158/1940-6207.capr-20-0367
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Brenner,DeanE
中科院分区：
文献类型：
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作者：
Colacino,Justin;Djuric,Zora;Brenner,DeanE
肥胖是与癌症风险有关的第二大环境因素；然而，人们对肥胖导致癌症发生的机制知之甚少。Holowatyj及其同事在本期《癌症预防研究》上发表的论文，利用在侵袭性结直肠癌患者手术中收集的样本，探索了人类内脏脂肪-上皮信号传递的机制。他们确定了可能参与调节纤维化、炎症、糖化和肿瘤组织上皮-间充质转变的途径中间体。“基于OMICS的围术期人体生物样本分析可能存在固有的偏见(术前和术中的药物治疗、水合作用、动力学、对手术干预的炎症反应)，并且难以识别和收集适当的对照样本。这一困境的解决方案可能包括识别接受类似手术但没有肿瘤的患者的策略，例如，有妇科问题的患者，疑似阑尾炎的腹部探查患者，症状或胆结石疾病切除患者，或正在接受减肥手术的患者。随着这一领域的持续发展，纳入强有力的统计分析、在不同队列中验证发现和公共数据共享的研究将是识别肥胖和癌症之间联系的生物学途径的关键，以便使用有重点的、假设驱动的方法进一步研究。参见Holowatyj等人的相关文章，第817页
Obesity is the second leading environmental association with cancer risk; yet, the mechanisms by which obesity drives carcinogenesis are poorly understood. The paper published in this issue of Cancer Prevention Research by Holowatyj and colleagues explores the mechanisms of human visceral adipose–epithelial signaling using samples collected at surgery in patients with invasive colorectal cancer. They identify pathway intermediates potentially involved in the regulation of fibrosis, inflammation, glycosis, and epithelial–mesenchymal transition in neoplastic tissue. ‘Omics-based profiling of perioperative human biosamples has potential for inherent biases (preoperative and intraoperative drug therapies, hydration, dynamics, inflammatory response to surgical intervention) and appropriate control samples are difficult to identify and collect. Solutions to this dilemma may include strategies to identify patients undergoing similar surgical procedures but who are without neoplasms, for example, patients with gynecologic problems, abdominal exploration for suspected appendicitis, symptoms or resection of gall stone disease or undergoing bariatric surgery. As the field continues to grow, studies incorporating robust statistical analyses, validation of findings in diverse cohorts, and public data sharing will be essential to identify biological pathways linking obesity and carcinogenesis to be further interrogated using focused, hypothesis-driven approaches.See related article by Holowatyj et al., p. 817