EFFECTS OF ALPHA-TOCOPHEROL AND BETA-CAROTENE SUPPLEMENTS ON CANCER INCIDENCE IN THE ALPHA-TOCOPHEROL BETA-CAROTENE CANCER PREVENTION STUDY
EFFECTS OF ALPHA-TOCOPHEROL AND BETA-CAROTENE SUPPLEMENTS ON CANCER INCIDENCE IN THE ALPHA-TOCOPHEROL BETA-CAROTENE CANCER PREVENTION STUDY
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DOI：
10.1093/ajcn/62.6.1427s
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发表时间：
1995-12-01
影响因子：
7.1
通讯作者：
GREENWALD, P
中科院分区：
文献类型：
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作者：
ALBANES, D;HEINONEN, OP;GREENWALD, P
α -生育酚-胡萝卜素（ATBC）癌症预防研究是一项安慰剂对照的随机干预试验，旨在验证β -胡萝卜素和α -生育酚（维生素E）补充剂可以预防肺癌和其他癌症的假设。这项研究是基于大量证据支持这些微量营养素在预防癌症方面的作用。基于2 × 2因子研究设计，29 133名年龄在50-69岁的符合条件的男性吸烟者被随机分配到每天服用β -胡萝卜素（20毫克）、α -生育酚（50毫克）、β -胡萝卜素和α -生育酚或安慰剂，持续5-8年。胶囊依从性高（中位数= 99%）。β -胡萝卜素治疗并没有导致任何主要部位的癌症减少，而是导致几个部位的癌症增加，最明显的是肺癌、前列腺癌和胃癌（病例数分别为474例对402例，138例对112例，70例对56例）。与没有服用维生素E的那一组相比，服用维生素E的那一组患前列腺癌和结直肠癌的几率更低（病例数分别为99例和151例，68例和81例），但患胃癌的几率更高（70例比56例）。与这些基于干预的β -胡萝卜素和维生素E补充剂的研究结果相反，我们观察到在基线时血清和饮食中β -胡萝卜素和维生素E含量较高的男性肺癌发病率较低。
The Alpha-Tocopherol Beta-Carotene (ATBC) Cancer Prevention Study was a placebo-controlled, randomized intervention trial testing the hypothesis that beta-carotene and alpha-tocopherol (vitamin E) supplements prevent lung and other cancers. The study is predicated on a substantial body of evidence supporting a role in cancer prevention for these micronutrients. Based on the 2 x 2 factorial study design, 29 133 eligible male cigarette smokers aged 50-69 y were randomly assigned to receive beta-carotene (20 mg), alpha-tocopherol (50 mg), beta-carotene and alpha-tocopherol, or placebo daily for 5-8 y. Capsule compliance was high (median = 99%). beta-Carotene treatment did not result in a decrease in cancer at any of the major sites but rather in an increase at several sites, most notably lung, prostate, and stomach (number of cases 474 compared with 402, 138 compared with 112, and 70 compared with 56, respectively). The vitamin E group had fewer incident cancers of the prostate and colorectum compared with the group not receiving vitamin E (number of cases 99 compared with 151 and 68 compared with 81, respectively), but more cancers of the stomach (70 compared with 56). In contrast to these intervention-based findings for beta-carotene and vitamin E supplements, we observed lower lung cancer rates in men with higher amounts of both serum and dietary beta-carotene and vitamin E at baseline.