The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children
The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children
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血脂在中国超重和肥胖儿童BMI与血压关系中的重要性
DOI：
10.1017/s0007114516001744
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发表时间：
2016-07-14
影响因子：
3.6
通讯作者：
Ma, Jun
中科院分区：
文献类型：
--
作者：
Zou, Zhi-yong;Yang, Yi-de;Ma, Jun
我们的目的是研究血脂对超重和肥胖儿童体重指数和血压之间的关系的影响。数据收集于2012年北京市朝阳区中小学校，中国。受试者的体重、身高、血压和空腹血脂按标准方案测量。以年龄为协变量，进行中介分析，考察血脂在BMI与BP关系中的中介作用。我们发现，在男孩中，829%的BMI与收缩压之间的关联是通过TAG中介的(中介效应=0106，P=0012)。TAG和低密度脂蛋白分别介导了1253%(中介效应=0093，P=0018)和775%(中介效应=057，P=0046)的BMI与舒张压的关系。然而，血脂在女孩中并没有表现出中介作用。我们的发现表明，血脂对BMI和BP之间的关系的贡献存在性别差异。控制TAG或低密度脂蛋白-胆固醇可能有利于降低超重男孩BMI相关性高血压的风险；然而，控制女孩的TAG或低密度脂蛋白-胆固醇则不是这样。这项研究可能为探索肥胖与高血压之间关联的潜在机制提供线索。
We aimed to examine the contribution of blood lipids to the association between BMI and blood pressure (BP) in children with overweight and obesity. Data were collected in elementary and high schools of Chaoyang District, Beijing, China in 2012. Participants' weight, height, BP and fasting plasma lipid profile were measured by standard protocols. Mediation analysis was used to examine the mediation role of blood lipids on the relation between BMI and BP, with age included as a covariate. We found that in boys 829 % (mediation effect=0106, P=0012) of the association between BMI and systolic BP was mediated through TAG. TAG mediated 1253 % (mediation effect=0093, P=0018) and LDL-cholesterol mediated 775 % (mediation effect=057, P=0046) of the association between BMI and diastolic BP was mediated by TAG and LDL-cholesterol, respectively. However, blood lipids did not show the mediation effect in girls. Our findings suggested that there was a sex difference in the contribution of blood lipids to the association between BMI and BP. Controlling TAG or LDL-cholesterol may be beneficial for reducing the risk of the BMI-related high BP in overweight boys; however, this outcome is not the case when controlling TAG or LDL-cholesterol in girls. This study may provide clues to explore the underlying mechanism of the association between obesity and hypertension.