The relevance of in vitro smooth muscle experiments to cerebral vasospasm.
The relevance of in vitro smooth muscle experiments to cerebral vasospasm.
复制标题
体外平滑肌实验与脑血管痉挛的相关性。
DOI：
10.1161/01.str.16.4.573
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发表时间：
1985
期刊：
影响因子：
8.3
通讯作者：
Zervas,NT
中科院分区：
文献类型：
--
作者：
Wellum,GR;Peterson,JW;Zervas,NT
概述可能有助于脑血管痉挛的发展的可能因素，特别强调痉挛产生的可能性，从平滑肌细胞的调节或收缩过程的功能障碍。强调这种可能性是因为细胞损伤和血管痉挛延迟发生的证据提示病理改变。有关痉挛在体内的发展数据进行了审查，并在可能的范围内，与脑血管平滑肌收缩性的体外研究。正常脑动脉的短期体外研究可能与仅在初始损伤延迟数天后发生的长期和严重脑血管收缩无关。
An overview of the possible factors that might contribute to the development of cerebral vasospasm is presented, with particular emphasis on the possibility that spasm arises from a malfunction of the regulatory or contractile processes in smooth muscle cells. This possibility is emphasized because the evidence for cellular damage and the delayed occurrence of vasospasm are suggestive of pathological alteration. Data regarding the development of spasm in vivo has been reviewed and, to the extent possible, correlated with in vitro studies of cerebrovascular smooth muscle contractility. Short-term in vitro studies of normal cerebral arteries may be of little relevance to the prolonged and severe cerebral vasoconstriction that occurs only after a delay of several days from the initial insult.