Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions
Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions
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DOI：
10.1016/j.physbeh.2005.02.007
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发表时间：
2005-03-31
影响因子：
2.9
通讯作者：
Ursin, R
中科院分区：
文献类型：
--
作者：
Gronli, J;Murison, R;Ursin, R
人类抑郁症的许多症状也在动物暴露于不可预测的压力后观察到。慢性轻度压力（CMS）范式是为了更好地模拟人类的情况下，使用慢性轻度压力在一个较长的时间。据称，该模型在动物中诱导快感缺失，这是人类抑郁症的核心症状。尽管CMS模型具有高度的表面有效性，但有一些实验室的模型建立不太可靠。我们已经检查了行为（性活动和开放领域的活动）与享乐措施（蔗糖和糖精摄入量）后，暴露于CMS。CMS降低了男性的性活动（例如，射精能力降低），并增加了开放领域的活动。在我们的实验室中，在CMS之后，享乐度量显示出不同的结果。蔗糖消耗量减少，而糖精消耗量没有显示出可比的变化。它的结论是CMS诱导类似的改变，一些抑郁症样症状在人类。尼古丁消耗不是CMS享乐反应的可靠指标。(c)2005年爱思唯尔公司All rights reserved.
Many symptoms of human depressive disorders are also observed in animals after exposure to unpredictable stressors. The chronic mild stress (CMS) paradigm was developed in order to better model the human situation by using chronic mild stressors over a longer period. It is claimed that the model induces anhedonia in the animals, a core symptom of depression in humans. Despite the fact that the CMS model has a high degree of face validity, there are a number of laboratories in which the establishment of the model is less reliably observed. We have examined behavior (sexual activity and open field activity) together with hedonic measures (sucrose and saccharine intake) after exposure to CMS. CMS decreased male sexual activity (e.g. reduced capability to ejaculate) and increased activity in an open field test. The hedonic measures showed diverging results after CMS in our laboratory. Sucrose consumption was reduced, while saccharine consumption did not show a comparable change. It is concluded that CMS induces comparable alterations to some depression-like symptoms in humans. Saccharine consumption is not a reliable indicator of the hedonic responsiveness to CMS. (c) 2005 Elsevier Inc. All rights reserved.