Imprinted polymer beads enabling direct and selective molecular separation in water
Imprinted polymer beads enabling direct and selective molecular separation in water
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DOI：
10.1039/c2sm25574j
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发表时间：
2012-06
期刊：
影响因子：
3.4
通讯作者：
Xiantao Shen;Changgang Xu;L. Ye
中科院分区：
文献类型：
--
作者：
Xiantao Shen;Changgang Xu;L. Ye
本文采用纳米粒子稳定乳液聚合法合成了水溶性分子印迹聚合物微球。在聚合过程中，致孔剂的用量不仅影响Pickering乳液的稳定性，而且影响所得MIP微球的特异性分子识别。在优化的条件下，合成的MIP微球具有多孔和亲水性的表面。扫描电镜和荧光标记实验表明，MIP微球粒径为165 ± 38 μm。在纯水条件下，通过平衡结合分析和液相色谱实验研究了MIP微球的选择性分子识别。采用新型MIP微球作为固相萃取（SPE）吸附剂，可有效富集自来水中的低浓度有机污染物（β-阻滞剂），并可利用HPLC-MS进行检测。
In this paper, we describe the synthesis of water-compatible Molecularly Imprinted Polymer (MIP) microspheres by nanoparticle-stabilized emulsion (Pickering emulsion) polymerization. During the polymerization, the amount of the porogen used not only affected the stability of the Pickering emulsion but also the specific molecular recognition of the obtained MIP microspheres. Under optimized conditions, the MIP microspheres synthesized had a porous and hydrophilic surface. Scanning electron microscopy and fluorescent labeling experiments indicated that the MIP microspheres had particle sizes of 165 ± 38 μm. Selective molecular recognition with the MIP microspheres was studied through equilibrium binding analysis and liquid chromatography experiments under pure aqueous conditions. Using the new MIP microspheres as solid phase extraction (SPE) absorbents, low concentration organic pollutants (β-blockers) were effectively enriched from tap water and easily detected using HPLC-MS analysis.