Cavity-enhanced optical methods for online microfluidic analysis
Cavity-enhanced optical methods for online microfluidic analysis
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DOI：
10.1016/j.cplett.2012.10.009
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发表时间：
2012-12-03
影响因子：
2.8
通讯作者：
Vallance, Claire
中科院分区：
文献类型：
--
作者：
Rushworth, Cathy M.;Davies, Joanna;Vallance, Claire
吸收光谱学是一种潜在的具有吸引力的微流控检测技术，因为它是通用的、无标记的、快速的。然而，通过微流控通道的短光程常常对检测灵敏度施加不可接受的限制。我们回顾了增加光程长度从而提高吸收测量的检测灵敏度的各种策略，包括延长光程长度的单程测量方法、多程测量方法，最后是一系列腔增强方法。我们的结论是，腔增强方法在需要在较小的探测体积内具有高检测灵敏度的应用中显示出相当大的前景。(C)2012爱思唯尔B.V.保留所有权利。
Absorption spectroscopy is potentially an attractive detection technique for microfluidic applications, as it is universal, label-free, and rapid. However, the short optical pathlength through a microfluidic channel often imposes unacceptable limits on the detection sensitivity. We review a variety of strategies for increasing the pathlength and thereby improving the detection sensitivity of absorption measurements, covering extended-pathlength single-pass methods, multi-pass measurements, and finally a range of cavity-enhanced methods. We conclude that cavity-enhanced approaches show considerable promise for applications in which a high detection sensitivity is required within a small probed volume. (C) 2012 Elsevier B. V. All rights reserved.