The Contribution of Visceral Adiposity and Mid-Thigh Fat-Rich Muscle to the Metabolic Profile in Postmenopausal Women
The Contribution of Visceral Adiposity and Mid-Thigh Fat-Rich Muscle to the Metabolic Profile in Postmenopausal Women
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DOI：
10.1038/oby.2010.348
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发表时间：
2011-05-01
期刊：
影响因子：
6.9
通讯作者：
Weisnagel, Stanley J.
中科院分区：
文献类型：
--
作者：
Dube, Marie-Christine;Lemieux, Simone;Weisnagel, Stanley J.
本研究探讨了绝经后女性大腿中部计算机断层扫描 (CT) 扫描产生的肌肉脂肪浸润、中央脂肪分布与胰岛素敏感性之间的关系。大腿中部 CT 扫描用于测量低衰减肌肉表面 (LAMS)（0-34 亨斯菲尔德单位 (HU)），它代表富含脂肪的肌肉的特定组成部分。通过正常血糖-高胰岛素钳夹评估全身胰岛素敏感性（M/I）。对 103 名年龄 57.0 +/- 4.4 岁的女性进行了研究。 LAMS 水平较高的女性表现出较高的代谢风险特征，特别是空腹、2 小时血浆葡萄糖 (2hPG) 浓度升高和 M/I 降低（P < 0.05）。为了进一步研究肌肉脂肪浸润和中心脂肪对代谢参数的贡献，我们根据 LAMS 和内脏脂肪组织 (VAT) 的中位数对整个组进行分组。正如预期的那样，低 LAMS/低 VAT 组的代谢特征最佳，而高 LAMS/高 VAT 组的代谢特征最差。低 LAMS/高 VAT 的女性与高 LAMS/高 VAT 的女性表现出相似的代谢风险。高 LAMS/低 VAT 和低 LAMS/低 VAT 之间没有差异，后者呈现出最健康的代谢和血糖状况，如最低水平的心血管疾病风险变量所反映。这表明高 LAMS/低 VAT 的代谢恶化风险也较低，并且仅在高 VAT 存在的情况下，高 LAMS 似乎与恶化的风险相关。尽管大腿中部富含脂肪的肌肉增加与代谢状况恶化有关，但增值税似乎是绝经后女性代谢状况改变的更重要因素。
This study explored the relationship between muscle fat infiltration derived from mid-thigh computed tomography (CT) scan, central fat distribution and insulin sensitivity in postmenopausal women. Mid-thigh CT scans were used to measure low attenuation muscle surface ( LAMS) (0-34 Hounsfield units (HU)), which represented a specific component of fat-rich muscle. Whole- body insulin sensitivity (M/I) was evaluated by an euglycemic-hyperinsulinemic clamp. A group of 103 women aged 57.0 +/- 4.4 years was studied. Women with higher levels of LAMS presented higher metabolic risk features, particularly elevated fasting, 2-h plasma glucose (2hPG) concentrations and diminished M/I (P < 0.05). To further study the contribution of muscle fat infiltration and central adiposity on metabolic parameters, we divided the whole group based on the median of LAMS and visceral adipose tissue ( VAT). As expected, the best metabolic profile was found in the Low-LAMS/Low-VAT group and the worst in the High-LAMS/High-VAT group. Women with Low-LAMS/High-VAT presented similar metabolic risks to those with High-LAMS/High-VAT. There was no difference between High-LAMS/Low-VAT and Low-LAMS/Low-VAT, which presents the most healthy metabolic and glycemic profiles as reflected by the lowest levels of cardiovascular disease risk variables. This suggests that High-LAMS/Low-VAT is also at low risk of metabolic deteriorations and that High-LAMS, only in the presence of High-VAT seems associated with deteriorated risks. Although increased mid-thigh fat-rich muscle was related to a deteriorated metabolic profile, VAT appears as a more important contributor to alterations in the metabolic profile in postmenopausal women.