Zebrafish: a genetic approach in studying hematopoiesis.
Zebrafish: a genetic approach in studying hematopoiesis.
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DOI：
10.1097/00062752-200003000-00002
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发表时间：
2000-03
影响因子：
3.2
通讯作者：
Barry H. Paw;Leonard I. Zon
中科院分区：
文献类型：
--
作者：
Barry H. Paw;Leonard I. Zon
斑马鱼（Danio rerio）近年来已成为研究脊椎动物器官发育，特别是造血系统发育的令人兴奋的动物模型系统。发育生物学和斑马鱼突变遗传筛选的综合优势为造血早期事件提供了见解，并确定了脊椎动物正常血液发育所需的几个基因。作为大规模诱变筛选发育突变体的结果，已经回收了几个具有血液发育缺陷的斑马鱼突变体。本文综述了斑马鱼的这些血液突变如何为造血发育提供了新的视角。
The zebrafish (Danio rerio) has emerged in recent years as an exciting animal model system for studying vertebrate organ development and, in particular, the development of the hematopoietic system. The combined advantages of developmental biology and genetic screens for mutations in zebrafish have provided insights into early events in hematopoiesis and identified several genes required for normal blood development in vertebrates. As a result of the large-scale mutagenesis screens for developmental mutants, several zebrafish mutants with defects in blood development have been recovered. This review discusses how these blood mutations in zebrafish have given new perspectives on hematopoietic development.