A protein immunologically related to erythrocyte band 4.1 is found on stress fibres of non-erythroid cells
A protein immunologically related to erythrocyte band 4.1 is found on stress fibres of non-erythroid cells
复制标题
在非红细胞的应力纤维上发现了与红细胞带 4.1 免疫学相关的蛋白质
作者：
C. M. Cohen;S. Foley;C. Korsgren
红细胞带 4.1 是红细胞细胞骨架的三种主要结构蛋白之一，另外两个是血影蛋白和肌动蛋白 1-3。当结合到肌动蛋白结合蛋白血影蛋白的尾端时，条带 4.1 能够促进与血影蛋白和 F-肌动蛋白4-7 在溶液中和红细胞膜上形成稳定的三元复合物8。最近的研究表明，在免疫学和结构上与血影蛋白以及锚蛋白（血影蛋白的膜附着位点）相关的蛋白质存在于多种非红系细胞中9-13，尽管这些蛋白质在此类细胞中的功能仍不清楚。据报道 14 条带 4.1 存在于血小板和粒细胞中。在这里，我们发现与带 4.1 免疫学相关的蛋白质存在于非红系细胞（成纤维细胞）中，并且通过免疫荧光标记显示沿着应力纤维均匀分布。我们认为，通过与红细胞带 4.1 类比，该蛋白可能是辅助肌动蛋白结合蛋白，并且可能用于整合肌动蛋白丝和肌动蛋白结合蛋白。
Erythrocyte band 4.1 is one of the three major structural proteins of the erythrocyte cytoskeleton, along with spectrin and actin1–3. When bound to the tail-end of the actin-binding protein spectrin, band 4.1 is capable of promoting the formation of stable ternary complexes with spectrin and F-actin4–7, both in solution and on the erythrocyte membrane8. Recent work has demonstrated that proteins immunologically and structurally related to spectrin, as well as ankyrin—spectrin's membrane attachment site—are present in a wide variety of non-erythroid cells9–13, although the function of these proteins in such cells is still unclear. It has been reported14 that band 4.1 is present in platelets and granulocytes. Here we show that a protein immunologically related to band 4.1 is present in a non-erythroid cell, the fibroblast, and appears by immunofluorescent labelling to be distributed uniformly along stress fibres. We suggest that by analogy with erythrocyte band 4.1 this protein may be an accessory actin-binding protein, and may serve to integrate actin filaments and actin-binding proteins.
微管相关蛋白 2 是一种来自大脑的微管相关蛋白，与红细胞血影蛋白的 α 亚基具有免疫相关性。
DOI：
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发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Davis,J;Bennett,V
通讯作者：
Bennett,V
红细胞膜骨骼蛋白条带4.1a和b是序列相关的磷蛋白。
DOI：
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发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Goodman,SR;Yu,J;Whitfield,CF;Culp,EN;Posnak,EJ
通讯作者：
Posnak,EJ