The discovery of natalizumab, a potent therapeutic for multiple sclerosis.
The discovery of natalizumab, a potent therapeutic for multiple sclerosis.
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DOI：
10.1083/jcb.201207175
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发表时间：
2012-10-29
期刊：
影响因子：
--
通讯作者：
Steinman L
中科院分区：
文献类型：
--
作者：
Steinman L
多发性硬化（MS）是中枢神经系统的主要炎性脱髓鞘疾病。有强有力的证据表明，大脑中的免疫反应是该疾病的关键组成部分。1992年，在学术界和生物技术界的合作中，我和我的同事发现α4整合素是参与免疫细胞归巢到发炎大脑中的关键分子。这些结果导致了MS药物的开发，这纯粹是运气吗？
Multiple sclerosis (MS) is the major inflammatory demyelinating disease of the central nervous system. There is strong evidence that an immune response in the brain is a critical component of the disease. In 1992, in a collaboration between academia and biotechnology, my colleagues and I showed that α4 integrin was the critical molecule involved in the homing of immune cells into the inflamed brain. Was it sheer luck that these results led to the development of a drug for MS?