The Mohawk homeobox gene is a critical regulator of tendon differentiation
The Mohawk homeobox gene is a critical regulator of tendon differentiation
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DOI：
10.1073/pnas.1000525107
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发表时间：
2010-06-08
影响因子：
11.1
通讯作者：
Asahara, Hiroshi
中科院分区：
文献类型：
--
作者：
Ito, Yoshiaki;Toriuchi, Naoya;Asahara, Hiroshi
Mohawk（Mkx）是在发育中的肌腱中表达的非典型同源异型盒基因的三氨基酸环延伸超类的成员。为了研究Mkx的体内功能，我们产生了Mkx（-/-）小鼠。这些小鼠全身肌腱发育不全。尽管肌腱质量减少，但野生型和Mkx（-/-）小鼠之间尾肌腱纤维束中的细胞数量相似。我们还观察到小的胶原纤维直径和下调Mkx（-/-）肌腱中的I型胶原。这些数据表明，Mkx通过调节肌腱细胞中I型胶原的产生在肌腱分化中起关键作用。
Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.