Everyday discrimination and telomere length in a multiethnic cohort of breast cancer survivors
Everyday discrimination and telomere length in a multiethnic cohort of breast cancer survivors
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DOI：
10.1080/13557858.2020.1739231
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发表时间：
2020-03-17
影响因子：
3.1
通讯作者：
Gomez, Scarlett Lin
中科院分区：
文献类型：
--
作者：
Aghaee, Sara;Allen, Amani;Gomez, Scarlett Lin
目的：与白色女性相比，种族/少数民族女性的乳腺癌生存率不成比例地低。由于美国的少数民族受到更高程度的歧视，并且受到歧视与较短的端粒长度（TL）相关，我们调查了多种族乳腺癌幸存者样本中感知的日常歧视与TL之间的关联。设计：我们研究了58名乳腺癌幸存者，他们参加了一项初步研究，以调查生物应激。参与者来自乳腺癌护理平等（EBCC）研究，并被要求提供唾液样本用于DNA提取。使用普通最小二乘线性回归推导回归系数（β）和95%置信区间（CI）。结果如下：更高水平的日常歧视与更长的TL相关（e（beta）= 1.04，CI：1.01-1.07），调整了年龄，种族/民族，乳腺癌分期和乳腺癌亚型。管腔型B亚型与较长的端粒相关，而非裔美国人比白人更不可能有较长的端粒。结论：需要进一步研究，特别是纵向研究，以了解歧视和其他社会压力因素如何影响生物压力和健康结果。
Objectives: Racial/ethnic minority women have disproportionately lower breast cancer survival rates compared to white women. As minorities in the US are exposed to higher levels of discrimination, and exposure to discrimination has been associated with shorter telomere lengths (TLs), we investigated the association between perceived everyday discrimination and TL in a multiethnic sample of breast cancer survivors. Design: We examined a cohort of 58 breast cancer survivors who participated in a pilot study to investigate biological stress. Participants were drawn from the Equality in Breast Cancer Care (EBCC) study and were asked to provide saliva samples for DNA extraction. Ordinary least squares linear regression was used to derive regression coefficients (beta) and 95% confidence intervals (CI). Results: Higher levels of everyday discrimination were associated with longer TLs (e(beta) = 1.04, CI: 1.01-1.07), adjusting for age, race/ethnicity, breast cancer stage, and breast cancer subtype. Luminal B subtypes were associated with longer telomeres relative to luminal A, while African Americans were less likely than Whites to have longer telomeres. Conclusions: Further research, particularly longitudinal studies, is needed to understand how discrimination, and other social stressors, impact biological stress and health outcomes.