Transcranial Direct Current Brain Stimulation Increases Ability to Resist Smoking.
Transcranial Direct Current Brain Stimulation Increases Ability to Resist Smoking.
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DOI：
10.1016/j.brs.2015.10.004
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发表时间：
2016-03
影响因子：
7.7
通讯作者：
Lerman C
中科院分区：
文献类型：
--
作者：
Falcone M;Bernardo L;Ashare RL;Hamilton R;Faseyitan O;McKee SA;Loughead J;Lerman C
对诱惑进行自我控制的能力是吸烟行为改变的基本组成部分。背外侧前额叶皮层 (DLPFC) 的经颅直流电刺激 (tDCS) 已被证明可以调节认知控制回路。尽管之前的研究表明刺激可以减少对香烟的渴望和自我报告的吸烟，但尚未直接研究其对抵制吸烟能力的影响。我们评估了在经过验证的戒烟范例中，对左侧 DLPFC 进行单次 20 分钟 1.0 mA 阳极刺激以及对右侧眶上区域进行阴极刺激（与假刺激）对抵抗吸烟能力的影响。 25 名参与者以受试者内、双盲、随机和平衡的顺序完成了两次 tDCS 课程（主动刺激和假刺激），并有两周的冲洗期。隔夜戒烟后，参与者在出现吸烟相关提示的情况下接受 tDCS；他们可以选择随时吸烟，或者每戒烟 5 分钟即可获得 1 美元。 50分钟后，他们参加了一小时的随意吸烟活动。主要和次要结果分别是第一次吸烟的时间和吸烟量。在多元回归模型中，主动 tDCS（与假手术相比）显着增加了吸烟潜伏期（p = 0.02），并减少了治疗期间吸烟的总数（p = 0.014）。这些发现表明，对左侧 DLPFC 进行急性阳极刺激（对右侧眶上区域进行阴极刺激）可以提高抵抗吸烟的能力，支持 tDCS 戒烟治疗的治疗潜力。
The ability to exert self-control over temptation is a fundamental component of smoking behavior change. Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been shown to modulate cognitive control circuits. Although prior studies show that stimulation reduces cigarette craving and self-reported smoking, effects on ability to resist smoking have not been investigated directly. We assessed effects of a single 20-minute session of 1.0 mA anodal stimulation over the left DLPFC with cathodal stimulation over the right supra-orbital area (vs. sham stimulation) on ability to resist smoking in a validated smoking lapse paradigm. Twenty-five participants completed two tDCS sessions (active and sham stimulation) in a within-subject, double-blind, randomized and counterbalanced order with a two-week washout period. Following overnight abstinence, participants received tDCS in the presence of smoking related cues; they had the option to smoke at any time or receive $1 for every 5 minutes they abstained. After 50 minutes, they participated in a one hour ad libitum smoking session. Primary and secondary outcomes were time to first cigarette and cigarette consumption, respectively. In multiple regression models, active tDCS (compared to sham) significantly increased latency to smoke (p = 0.02) and decreased the total number of cigarettes smoked (p = 0.014) during the session. These findings suggest that acute anodal stimulation over the left DLPFC (with cathodal stimulation over the right supra-orbital area) can improve ability to resist smoking, supporting the therapeutic potential of tDCS for smoking cessation treatment.