Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230
Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230
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DOI：
10.1017/s0031182099005041
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发表时间：
1999-11-01
期刊：
影响因子：
2.4
通讯作者：
Riley, E
中科院分区：
文献类型：
--
作者：
Healer, J;McGuinness, D;Riley, E
对疟疾免疫的人血清测试了它们影响恶性疟原虫配子细胞对斯氏按蚊感染性的能力。血清的传播减少作用与配子表面蛋白Pfs230抗体的存在有关。在一些血清中观察到传播的增强，表现为与对照组相比卵囊数量增加，但没有发现与Pfs230抗体相关。这些结果证实了Pfs230可能是一种传播阻断疟疾疫苗的候选者。
Malaria-immune human sera were tested for their ability to affect the infectivity of Plasmodium falciparum gametocytes to Anopheles stephensi mosquitoes. Transmission-reducing effects of the sera were associated with the presence of antibodies to the gamete surface protein, Pfs230. Enhancement of transmission, manifest as elevated numbers of oocysts relative to controls, was observed fora number of sera, but was not found to be associated with antibodies against Pfs230. These results confirm that Pfs230 is a possible candidate for inclusion in a transmission-blocking malaria vaccine.