Imaging the Interaction: Epileptic Discharges, Working Memory, and Behavior
Imaging the Interaction: Epileptic Discharges, Working Memory, and Behavior
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DOI：
10.1002/hbm.22115
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发表时间：
2013-11-01
影响因子：
4.8
通讯作者：
Koepp, Matthias
中科院分区：
文献类型：
--
作者：
Chaudhary, Umair J.;Centeno, Maria;Koepp, Matthias
发作间期广泛性癫痫样放电可能损害认知。我们同时使用视频脑电图和功能成像来量化癫痫样放电引起的空间工作记忆范式中任务相关激活的变化。癫痫样放电的数量增加，在其复杂程度的任务，但没有显着相关的错误反应在任务。在无痫样放电的情况下，我们观察了与工作记忆相关的额叶网络、运动皮层、楔前叶和顶叶的血流动力学反应。在任务过程中癫痫样放电的存在下，任务相关的血流动力学变化仅见于运动皮层，楔前叶和顶叶。这些结果表明，在高要求的工作记忆任务中的广泛性癫痫样放电可能会改变额叶网络的工作记忆相关的血流动力学反应。《脑地图》34：2910-2917，2013年。(c)2012 Wiley Periodicals，Inc.
Interictal generalized epileptiform discharges may impair cognition. We used simultaneous video-electroencephalography and functional imaging to quantify changes, induced by epileptiform discharges, in the task-related activations during a spatial working-memory paradigm. The number of epileptiform discharges increased during the task with its level of complexity, but were not significantly associated with wrong responses during the task. We observed hemodynamic responses in working-memory related frontal-lobe-network, motor-cortex, precuneus, and parietal lobes in the absence of epileptiform discharges. In the presence of epileptiform discharges during the task, task-related hemodynamic changes were seen only in motor-cortex, precuneus, and parietal lobes. These findings suggest that generalized epileptiform discharges during a high demanding working memory task may change the working memory-related hemodynamic responses in frontal-lobe-network. Hum Brain Mapp 34:2910-2917, 2013. (c) 2012 Wiley Periodicals, Inc.