An exploratory study of articular cartilage and subchondral bone reconstruction with bone marrow mesenchymal stem cells combined with porous tantalum/Bio-Gide collagen membrane in osteonecrosis of the femoral head
An exploratory study of articular cartilage and subchondral bone reconstruction with bone marrow mesenchymal stem cells combined with porous tantalum/Bio-Gide collagen membrane in osteonecrosis of the femoral head
复制标题
DOI：
10.1016/j.msec.2019.02.072
复制
发表时间：
2019-06-01
影响因子：
7.9
通讯作者：
Zhao, Dewei
中科院分区：
文献类型：
--
作者：
Liu, Baoyi;Yang, Fan;Zhao, Dewei
股骨头坏死（ONFH）导致股骨头塌陷和髋关节快速破坏。塌陷后关节软骨和软骨下骨的修复具有挑战性。通过X线片确定股骨头缺血性坏死后，切断股骨头血供，建立全层关节缺损动物模型。将多孔钽和Bio-Gide胶原膜与骨髓间充质干细胞（BMSCs）体外共培养，植入缺损区修复全层关节缺损。术后12周，在缺损边缘附近的钽顶部检测到透明软骨。多孔钽和Bio-Gide胶原膜与BMSCs可以修复全层关节缺损，如果血液供应可以重建后塌陷阶段的ONFH。
Osteonecrosis of the femoral head (ONFH) results in collapse of the femoral head and rapid destruction of the hip joint. The repair of post-collapse articular cartilage and subchondral bone is challenging. We interrupted the blood supply to the femoral head and established a full-thickness articular defect animal model after ONFH was determined via X-ray. Porous tantalum and a Bio-Gide collagen membrane, co-cultured with bone marrow mesenchymal stem cells (BMSCs) in vitro, were implanted into the defect zone to repair the full-thickness articular defect. Hyaline cartilage was detected on top of the tantalum near the edge of the defect 12 weeks post-operatively. Porous tantalum and a Bio-Gide collagen membrane with BMSCs may repair full-thickness articular defects if the blood supply can be reconstructed in the post-collapse stage of ONFH.