Choline- and betaine-defined diets for use in clinical research and for the management of trimethylaminuria
Choline- and betaine-defined diets for use in clinical research and for the management of trimethylaminuria
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DOI：
10.1016/j.jada.2004.09.027
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发表时间：
2004-12-01
影响因子：
--
通讯作者：
Zeisel, SH
中科院分区：
文献类型：
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作者：
Busby, MG;Fischer, L;Zeisel, SH
这篇文章描述了一系列控制胆碱和甜菜碱的饮食的发展，这些饮食作为正在进行的人类饮食需求研究的一部分，提供给研究对象。这些饮食是基于对个别食物中胆碱和甜菜碱的分析而制定的。计算出的饮食与每天所有食物组合成一个样本的分析结果进行比较。对全饮食等价物中胆碱和甜菜碱的实验室分析与对单个食物的分析计算出的饮食中的估计量相吻合。这些饮食根据胆碱和甜菜碱的不同水平进行了调整，并且在长达2个月的时间内被研究对象所接受。本文描述了这种饮食在人类甲基需求的临床研究中的应用，以及在临床实践中对需要控制胆碱饮食的病人进行咨询的应用。
This article describes the development of a series of choline- and betaine-controlled diets that were served to research subjects as part of an ongoing study of diet requirements in humans. These diets were developed based on the analysis of choline and betaine in individual foods. The calculated diets were compared with analyses of all foods combined into a single sample for each day. The laboratory analyses of choline and betaine in the whole-diet aliquots matched the estimated amounts in the diets that were calculated from the analyses of individual foods. These diets were adjusted for several levels of choline and betaine and were well accepted by research subjects who consumed them for a time period of up to 2 months. This article describes applications of this diet for use in clinical research on methyl-group requirements in humans and for use in clinical practice for counseling the client who requires a choline-controlled diet.