Structure of thermally activated TRP channels.
Structure of thermally activated TRP channels.
复制标题
DOI：
10.1016/b978-0-12-800181-3.00007-5
复制
发表时间：
2014
影响因子：
--
通讯作者：
Moiseenkova-Bell, Vera Y.
中科院分区：
文献类型：
--
作者：
Cohen, Matthew R.;Moiseenkova-Bell, Vera Y.
温度感觉对于生物体的适应和生存非常重要。虽然温度有可能影响所有生物大分子，但生物体已经进化出特定的热敏分子检测器，能够将温度变化转化为生理相关信号。在这些温度传感器中，有来自瞬时受体电位（TRP）家族的离子通道。主要候选者包括TRPV 1 -4、TRPA 1和TRPM 8（所谓的“thermoTRP”通道），它们在感觉神经元中表达并在特定温度下门控。电生理学和热力学方法已被用来确定thermoTRP检测温度和耦合温度变化通道门控的性质。为了进一步了解thermoTRP如何感知温度，需要全长thermoTRP通道的高分辨率结构。在这里，我们将讨论目前的进展，解开thermoTRP通道的结构。
Temperature sensation is important for adaptation and survival of organisms. While temperature has the potential to affect all biological macromolecules, organisms have evolved specific thermosensitive molecular detectors that are able to transduce temperature changes into physiologically relevant signals. Among these thermosensors are ion channels from the transient receptor potential (TRP) family. Prime candidates include TRPV1–4, TRPA1, and TRPM8 (the so-called “thermoTRP” channels), which are expressed in sensory neurons and gated at specific temperatures. Electrophysiological and thermodynamic approaches have been employed to determine the nature by which thermoTRPs detect temperature and couple temperature changes to channel gating. To further understand how thermoTRPs sense temperature, high-resolution structures of full-length thermoTRPs channels will be required. Here, we will discuss current progress in unraveling the structures of thermoTRP channels.