Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart
Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart
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DOI：
10.1161/01.cir.0000143072.36782.51
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发表时间：
2004-09-28
期刊：
影响因子：
37.8
通讯作者：
Ogawa, H
中科院分区：
文献类型：
--
作者：
Nakamura, S;Yoshimura, M;Ogawa, H
背景-醛固酮不仅在肾上腺中产生，而且在肾上腺外组织中也产生，包括衰竭的人类心脏。本研究探讨了生产脱氢表雄酮（DHEA）在人类心脏和阐明可能的生理significant.Method和结果，使用左心室组织在尸检中获得，逆转录聚合酶链反应，Southern印迹分析揭示了CYP 17的基因表达。通过测定心导管术中冠状窦和主动脉根部血浆醛固酮和脱氢表雄酮（DHEA）的含量，发现对照组有DHEA分泌，而无醛固酮分泌（P
Background-Aldosterone is produced not only in the adrenal gland but also in the extra-adrenal tissues, including failing human heart. This study examined the production of dehydroepiandrosterone (DHEA) in human heart and elucidated the possible physiological significance.Method and Results-Using left ventricular tissues obtained at autopsy, reverse transcription-polymerase chain reaction followed by Southern blot analysis revealed the gene expressions of CYP17. By measuring plasma aldosterone and DHEA levels at the coronary sinuses and aortic roots during cardiac catheterization, we found that DHEA but not aldosterone was secreted from control subjects (P