Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins
Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins
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DOI：
10.1016/s0168-0102(01)00297-8
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发表时间：
2001-12-01
影响因子：
2.9
通讯作者：
Taga, T
中科院分区：
文献类型：
--
作者：
Yanagisawa, M;Takizawa, T;Taga, T
骨形态发生蛋白（BMPs）是一类细胞因子，属于转化生长因子- β超家族，已被证明在发育过程中发挥多种作用，包括在中枢神经系统中。我们在此报道BMP2， BMP4和BMP7具有抑制神经发生并同时诱导小鼠胎儿神经上皮细胞星形细胞发生的同等潜力。我们进一步表明，这些bmp激活了负螺旋-环-螺旋（HLH）因子基因的启动子Id1，该因子已知可抑制神经源性转录因子如Mash1和神经源性转录因子的功能。这些结果表明，BMP2、BMP4和BMP7通过一种与负HLH因子有关的共同机制，使神经上皮细胞从神经元型转变为星形细胞型。(C) 2001爱思唯尔科学爱尔兰有限公司和日本神经科学学会。版权所有。
Bone morphogenetic proteins (BMPs), a class of cytokines belonging to the transforming growth factor-beta superfamily, have been shown to play a wide variety of roles during development including those in the central nervous system. We here report that BMP2, BMP4 and BMP7 have an equivalent potential to inhibit neurogenesis and concomitantly induce astrocytogenesis of mouse fetal neuroepithelial cells. We further show that these BMPs activate a promoter of the gene for negative helix-loop-helix (HLH) factor, Id1, which is known to inhibit the function of such neurogenic transcription factors as Mash1 and neurogenin. Those results suggest that BMP2, BMP4 and BMP7 alternate the fate of neuroepithelial cells from neuronal type to astrocytic one via a common mechanism involving negative HLH factor. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.