Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress.
Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress.
复制标题
脂肪酸合酶基因Val1483Ile多态性与心理压力影响下的抑郁症状相关。
DOI：
10.1016/j.jad.2011.05.010
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发表时间：
2011
影响因子：
6.6
通讯作者：
K. Shimoi
中科院分区：
文献类型：
--
作者：
H. Tsuboi;H. Sakakibara;K. Yamakawa‐Kobayashi;A. Tatsumi;Tomoko Inamori;Reiko Hamamoto;A. Suzuki;K. Shimoi
方法采用横断面研究方法，对日本某医院和疗养院的177名男性（n=15）和女性（n=166）进行了5-羟色胺转运体连接启动子区（5-HTTLPR）和脂肪酸合成酶基因（FXR）的多态性研究。使用流行病学研究中心抑郁量表（CES-D）评估抑郁症状，并使用视觉模拟量表（VAS）测量感知心理压力。采用PCR方法检测5-HTTLPR（插入/缺失; L/S）和FXR（Val 1483 Ile）基因型。以CES-D评分为因变量，VAS评分、基因多态性和混杂因素为自变量，进行线性回归分析。在感知压力的影响下，与L/L+L/S携带者相比，5-HTTLPR基因S/S携带者显示出显著更高的CES-D评分（F=8.2，标准化β=0.15，p<0.05）。回归分析还证实，具有Ile/Ile+瓦尔/Ile基因型的受试者的CES-D评分显著高于具有瓦尔/瓦尔基因型的受试者（F=8.4，标准化β=0.16，p<0.05）。在身体特征方面，5-HTTLPR的S/S基因型参与者的BMI显著低于L/L+L/S基因型参与者。5-HTTLPR基因S型变异与肥胖程度降低有关。
BACKGROUNDTo study the association between lipid-metabolism and depressive symptoms, genetic polymorphisms in serotonin transporter linked promoter region (5-HTTLPR) and fatty acid synthase gene (FASN) were investigated.METHODA cross-sectional study was conducted on 177 women (n=166) and men (n=15) recruited from workers in a hospital and nursing homes in Japan. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression (CES-D) scale and perceived psychological stress was measured using visual analogue scale (VAS). The genotypes of 5-HTTLPR (insertion/deletion; L/S), and FASN (Val1483Ile) were determined by the PCR methods. Linear regression analysis was performed, in which CES-D scores served as a dependent variable, and VAS scores, gene polymorphism, and confounders as independent variables.RESULTSUnder the influence of perceived stress, S/S carriers of the 5-HTTLPR gene showed significantly higher CES-D scores in comparison with L/L+L/S carriers (F=8.2, standardised β=0.15, p<0.05). Regression analysis also confirmed that CES-D scores in participants with Ile/Ile+Val/Ile genotypes of the FASN gene were significantly higher than those with Val/Val genotype (F=8.4, standardised β=0.16, p<0.05). In relation to physical features, BMI among participants with S/S genotype of 5-HTTLPR was significantly lower compared with those with L/L+L/S genotypes.CONCLUSIONSThe Val1483Ile polymorphism in the FASN was associated with depressive symptoms under the influence of psychological stress. The S variant of 5-HTTLPR was related with less obese.