MOS-SF-36 in evaluating health-related duality of life in alcohol-dependent patients
MOS-SF-36 in evaluating health-related duality of life in alcohol-dependent patients
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DOI：
10.3109/00952999809019617
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发表时间：
1998-01-01
影响因子：
2.7
通讯作者：
Yersin, B
中科院分区：
文献类型：
--
作者：
Daeppen, JB;Krieg, MA;Yersin, B
健康相关的生活质量（HRQoL）进行了评估，在酒精依赖患者的样本与36项医疗结果研究简表健康调查（MOS-SF-36）。该仪器被用于147名患者（77%为男性），年龄在26-78岁之间，具有DSM-III-R诊断的酒精依赖。对前100名患者进行汉密尔顿抑郁量表（HDS）、酒精依赖严重程度问卷（SADQ）和成瘾严重程度指数（AST）。评价MOS-SF-36的信度和效度。10天间隔的重测组内系数在0.65至0.79的范围内，而Cronbach α系数表明内部一致性良好（范围为0.70至0.89）。与在一般人群中观察到的评分相比，酒精依赖患者的MOS-SF-36评分相对较低（表明HRQoL感知较差），尤其是在心理和角色维度（范围52/100至55/100），但更接近身体和功能维度的人群值（范围61/100至75/100）。MOS-SF-36维度与HDS之间的最高相关性见于MOSSF-36“心理健康”维度（r = -.56，p < .001）;该维度也与ASI的精神病学维度高度相关（r = -.73，p < .001）。HDS ≥ 16（重度抑郁）的患者的MOS-SF-36的8个维度比HDS ≤ 7（无抑郁）的患者低21%至127%。“ASI酒精”评分高的患者的MOS-SF-36维度低10%至141%，表明HRQoL特征较差，酒精依赖严重程度较高。MOS-SF-36在酒精依赖患者中具有良好的信度和效度标准。结果表明，酒精依赖患者认为他们的问题更多的是心理上的，而不是身体上的。酒依赖和抑郁的严重程度对HRQoL有负性影响。
Health-related quality of life (HRQoL) was evaluated in a sample of alcohol-dependent patients with the 36-item Medical Outcome Study Short-Form Health Survey (MOS-SF-36). The instrument was administered to 147 patients (77% males), aged 26-78, with a DSM-III-R diagnosis of alcohol dependence. The Hamilton Depression Scale (HDS), the Severity of Alcohol Dependence Questionnaire (SADQ), and the Addiction Severity Index (AST) were also administered to the first 100 patients included in the study. The reliability and validity of the MOS-SF-36 were evaluated. Test-retest intraclass coefficients for a 10-day interval were in the range .65 to .79, whereas the Cronbach alpha coefficient indicated good internal consistency (range .70 to .89). Compared to scores observed in the general population, MOS-SF-36 scores for alcohol-dependent patients were relatively low (indicating worse perception of HRQoL), especially in the psychological and role dimensions (range 52/100 to 55/100), but were closer to populational values in the physical and functional dimensions (range 61/100 to 75/100. The highest correlation between MOS-SF-36 dimensions and HDS was found in the MOSSF-36 "mental health" dimension (r = -.56, p < .001); this dimension was also correlated highly with the psychiatric dimension of the ASI (r = -.73, p < .001). The eight dimensions of the MOS-SF-36 were 21% to 127% lower in patients with HDS greater than or equal to 16 (major depression) compared to those with HDS less than or equal to 7 (absence of depression). The MOS-SF-36 dimensions were 10% to 141% lower in patients with high "ASI alcohol" scores, indicating worse HRQoL profiles with a higher severity of alcohol dependence. The MOS-SF-36 presents good criteria for reliability and validity in alcohol-dependent patients. The results suggested that alcohol-dependent patients perceived their problems more as psychological than physical. The severity of alcohol dependence anti depression seemed to influence the perception of HRQoL negatively.