The ups and downs of life in an epithelium.
The ups and downs of life in an epithelium.
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上皮细胞生命的起起落落。
DOI：
10.1083/jcb.151.4.f15
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Krämer,H
中科院分区：
文献类型：
--
作者：
Krämer,H
极化的上皮层保护组织免受外部世界的恶劣条件，例如胚胎的外部或肠道的内腔。该“外部”面对上皮细胞的顶端结构域，其含有一组膜蛋白和细胞骨架元件，其不同于在细胞的基底外侧结构域上发现的蛋白质（Yeaman等人，1999年）。建立定义这些结构域的差异是上皮细胞面临的基本挑战之一。Journal of Cell Biology（Hunter和Wieschaus，2000; Lecuit和Wieschaus，2000; Sisson等人，2000; Tanentzapf等人，2000; Wodarz等人，2000）使用果蝇来探索这一过程，他们在果蝇、脊椎动物和哺乳动物的上皮细胞中发现了令人惊讶的相似之处。
Polarized epithelial layers protect tissues from the harsh conditions of the outside world, such as the outside of an embryo or the lumen of a gut. This “outside” is faced by an epithelial cell’s apical domain, which contains a set of membrane proteins and cytoskeletal elements that is distinct from the proteins found on the cell’s basolateral domain (Yeaman et al., 1999). Establishing the differences that define these domains is one of the fundamental challenges confronting an epithelial cell. Several recent papers in the Journal of Cell Biology (Hunter and Wieschaus, 2000; Lecuit and Wieschaus, 2000; Sisson et al., 2000; Tanentzapf et al., 2000; Wodarz et al., 2000) use Drosophila to explore this process, and they showed surprising parallels among epithelia in Drosophila, vertebrates, and