Overview of vaccination in chronic kidney disease
Overview of vaccination in chronic kidney disease
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DOI：
10.1053/j.ackd.2006.04.007
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发表时间：
2006-07-01
影响因子：
2.9
通讯作者：
Gilbertson, David T.
中科院分区：
文献类型：
--
作者：
Kausz, Annamaria T.;Gilbertson, David T.
感染是终末期肾病（ESRD）患者死亡的主要原因，仅次于心血管疾病，并且还导致早期慢性肾病（CKD）患者的显着发病率。疫苗是一种试图降低感染相关发病率的策略。患有 CKD 和 ESRD 的患者对疫苗的反应可能不如没有肾衰竭的患者，但已有证据表明，针对流感、乙型肝炎、肺炎球菌和水痘的疫苗接种标准或增强方案可产生足够的血清反应。尤其是流感，标准给药方案似乎可以提供足够的保护。尽管某些疫苗对 CKD 患者的有效性有所降低，但有新的证据表明疫苗接种对这些人群有益。然而，疫苗接种率相对较低。鉴于越来越多的益处证据，需要持续的质量改进计划，重点是提高各级 CKD 患者的疫苗接种率。 (C) 2006 年，国家肾脏基金会 (National Kidney Foundation, Inc.)
Infections are a major cause of death in end-stage renal disease (ESRD) patients, second only to cardiovascular disease, and also contribute to significant morbidity in patients with earlier stages of chronic kidney disease (CKD). Vaccines are a strategy to attempt to reduce morbidity related to infections. Patients with CKD and ESRD may not respond as well to vaccines as patients without kidney failure, but adequate seroresponse with standard or augmented regimens for vaccinations against influenza, hepatitis B, pneumococcus, and varicella have been documented. Influenza, in particular, seems to provide adequate protection with standard dosing regimens. Despite somewhat reduced effectiveness of certain vaccines in patients with CKD, there is emerging evidence of benefit to vaccination in these populations. However, vaccination rates are relatively low. Given the accumulating evidence of benefit, continuing quality improvement programs focused on increasing vaccination rates in patients with all levels of CKD are needed. (C) 2006 by the National Kidney Foundation, Inc.