Neuroanatomical correlation of behavioral deficits in the CCI model of TBI
Neuroanatomical correlation of behavioral deficits in the CCI model of TBI
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DOI：
10.1016/j.jneumeth.2010.04.004
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发表时间：
2010-06-30
影响因子：
3
通讯作者：
Chauhan, Mihirsinh B.
中科院分区：
文献类型：
--
作者：
Chauhan, Neelima B.;Gatto, Rodolfo;Chauhan, Mihirsinh B.
创伤性脑损伤 (TBI) 是战斗和平民情况下死亡和残疾的主要原因，治疗选择有限，包括手术切除血肿、脑室引流和使用高渗剂来限制 TBI 后的继发性损伤。具有与脑损伤相关的解剖和行为成分的全方位特征的适当模型系统的可用性提供了一个临床前平台来测试临床转化的候选疗法。使用受控皮质冲击损伤（CCI）进行 TBI 建模在很大程度上被认为与临床 TBI 接近，因此 CCI 模型已广泛应用于临床前 TBI 研究。迄今为止，大多数使用 CCI 模型的研究报告的行为特征都很有限，并且缺乏与 TBI 特征组织病理学的相关性。目前的研究在 TBI 的 CCI 小鼠模型中验证了与弥漫性轴突损伤（TBI 的标志性组织病理学）相关的详细感觉运动和认知行为特征。目前的研究提供了一个全面表征的 TBI 模型，可用于研究 TBI 背后的细胞和分子机制，并测试候选疗法，以开发新的有效的 TBI 治疗方法。由 Elsevier B.V. 出版
Traumatic brain injury (TBI) is the leading cause of death and disability both in combat and civilian situations with limited treatment options including surgical removal of hematoma, ventricular drainage and use of hyperosmotic agents that restrict secondary injury following TBI. Availability of appropriate model system with full-range characterization of anatomical and behavioral components correlative with brain injury provides a pre-clinical platform to test candidate therapies for clinical translation. Modeling of TBI using controlled cortical impact injury (CCI) is largely considered to be close to clinical TBI and hence CCI models have been widely used in pre-clinical TBI research. Most studies reported so far using CCI models were presented with a limited behavioral characterization and lacked its correlation with the signature histopathology of TBI. Current investigation validated a detailed sensomotor and cognitive behavioral characterization correlative with diffuse axonal injury-the signature histopathology of TBI, in the CCI mouse model of TBI. Present study offers a comprehensively characterized model of TBI that can be used to investigate cellular and molecular mechanisms underlying TBI and to test candidate therapies in developing novel and effective treatments for TBI. Published by Elsevier B.V.