ANTISPERMATOGENIC ACTION OF CELASTRUS-PANICULATUS SEED EXTRACT IN THE RAT WITH REVERSIBLE CHANGES IN THE LIVER
ANTISPERMATOGENIC ACTION OF CELASTRUS-PANICULATUS SEED EXTRACT IN THE RAT WITH REVERSIBLE CHANGES IN THE LIVER
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DOI：
10.1016/0378-8741(90)90080-d
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发表时间：
1990-03-01
影响因子：
5.4
通讯作者：
BHULLAR, N
中科院分区：
文献类型：
--
作者：
BIDWAI, PP;WANGOO, D;BHULLAR, N
本文研究了南蛇藤种子油提取物对成年大鼠睾丸和肝脏的生化、组织化学和组织学影响。给药动物的睾丸出现空泡化、生殖细胞耗竭和精子发生停滞。在每隔一天接受0.2 ml i.p.给药的动物中，肝脏显示局灶性坏死，持续30天，但给药后45天，这些病变消失。治疗后30天，中间修复和再生变化明显。这些结果表明，南蛇藤油可能具有有用的抗生育作用，并且随着时间的推移，肝脏中观察到的退行性变化是可逆的。
Biochemical, histochemical and histological studies of the effects of an oily extractive from the seeds of Celastrus paniculatus were done on the testes and liver of adult rats. The testis of treated animals showed vacuolization, germ cell depletion and arrest of spermatogenesis. The livers revealed focal necrosis in animals receiving 0.2 ml i.p. every other day for 30 days, but 45 days post treatment these lesions were absent. Intermediate repair and regenerative changes were apparent 30 days post treatment. These results indicate that Celastrus paniculatus oil may have useful antifertility effects and that the degenerative changes seen in the liver are reversible with time.