Anti-inflammatory Effect of Vitamin D on Gingivitis: A Dose-Response Randomised Control Trial
Anti-inflammatory Effect of Vitamin D on Gingivitis: A Dose-Response Randomised Control Trial
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DOI：
10.3290/j.ohpd.a29377
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发表时间：
2013-01-01
影响因子：
1.6
通讯作者：
Prasad, Kakrala Veera Venkatesha
中科院分区：
文献类型：
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作者：
Hiremath, Vishwanath P.;Rao, C. Bhasker;Prasad, Kakrala Veera Venkatesha
目的：评估不同剂量维生素 D 对牙龈炎的抗炎作用。 材料和方法：在这项随机对照试验中，A 组每天口服维生素 D 2000 IU，B 组 1000 IU，C 组 500 IU，D 组服用安慰剂，持续 3 个月。第1、2、3个月后测量牙龈评分的变化。结果：牙龈炎评分的变化与补充维生素D的剂量成正比。 A 组的平均牙龈评分为 2.4（基线），第一个月后为 1.7，第二个月后为 0.8，第三个月后为 0.3。 B组平均基线牙龈评分为2.3，第一个月下降至2.0，第二个月后下降至1.1，第三个月后下降至0.5。在 C 组中，一个月后基线牙龈评分为 2.2 和 1.9，两个月后为 1.4，最后一次就诊时为 0.8。使用Wilcoxon配对检验将基线牙龈炎评分与后期就诊评分进行比较，口服维生素D补充后1个月、B组2个月和C组3个月后观察到显着的抗炎效果（P < 0.0001）。但D组未表现出明显的抗炎作用。结论：维生素D对牙龈炎具有剂量依赖性的抗炎作用。维生素 D 是一种安全有效的抗炎剂，剂量范围为 500 IU 至 2000 IU。使用 2000 IU 的较高剂量，结果会更早显现。
Purpose: To assess the anti-inflammatory effect of vitamin D on gingivitis at various doses.Materials and Methods: In this randomized controlled trial, daily oral vitamin D supplementation was given in doses of 2000 IU for group A, 1000 IU for group B, 500 IU for group C and a placebo for group D over a 3-month period. The changes in gingival scores were measured after the 1st, 2nd and 3rd months.Results: The gingivitis score changed in direct proportion to the dose of vitamin D supplementation. In group A, the mean gingival scores were 2.4 (baseline), 1.7 after the first month, 0.8 after the second month and 0.3 after the third month. The group B mean baseline gingival score of 2.3 decreased to 2.0 in the first month, 1.1 after the second month and 0.5 after the third month. In group C, the baseline gingival scores were 2.2 and 1.9 after one month, 1.4 after two months and 0.8 by the last visit. Comparing baseline gingivitis scores with the later-visit score using the Wilcoxon paired test, the significant anti-inflammatory effect was seen in group A after one month, in group B at two months and in group C at three months after oral vitamin D supplementation (P < 0.0001). However, group D did not show a significant anti-inflammatory effect.Conclusion: There is a dose-dependent anti-inflammatory effect of vitamin D on gingivitis. Vitamin D is a safe and effective anti-inflammatory agent in doses ranging from 500 IU to 2000 IU. Results are apparent earlier with the higher dose of 2000 IU.