Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma
Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma
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新型抑癌基因SMG-1在肝细胞癌中的表达及意义
DOI：
10.3892/or.2014.3125
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发表时间：
2014-06-01
期刊：
影响因子：
4.2
通讯作者：
Nan, Ke-Jun
中科院分区：
文献类型：
--
作者：
Han, Li-Li;Nan, Hao-Cheng;Nan, Ke-Jun
SMG-1是磷脂酰肌醇3-激酶相关蛋白激酶（phosphatidylinositol 3-kinase-related protein kinases，PIKKs）家族的新成员，近年来的研究表明，SMG-1作为一种新的肿瘤抑制因子参与肿瘤的发生。然而，其在肝细胞癌（HCC）中的表达和意义尚不清楚。本研究调查了SMG-1在HCC组织标本中的表达，旨在确定其与临床病理学意义的相关性。采用免疫组化和qRT-PCR方法分析SMG-1在157例HCC和相应远处正常组织标本中的表达。结果显示SMG-1在肝癌组织中的表达明显低于远处正常组织。SMG-1的低表达水平与血清甲胎蛋白水平（P=0.001）、低分化肿瘤（P=0.009）和TNM分期（P
Recent studies have demonstrated that SMG-1, a newly characterized member of the family of phosphatidylinositol 3-kinase-related protein kinases (PIKKs), is involved in tumorigenesis as a new tumor suppressor. However, its expression and significance in hepatocellular carcinoma (HCC) remain obscure. The present study investigated SMG-1 expression in HCC tissue specimens, aimed at defining the association with clinicopathological significance. Both immunohistochemistry and qRT-PCR were employed to analyze SMG-1 expression in 157 HCC and corresponding distant normal tissue specimens. The results revealed that expression of SMG-1 was significantly lower in the HCC tissue specimens than that in the distant normal tissues. Moreover, a lower expression level of SMG-1 was significantly correlated with serum alpha-fetoprotein level (P=0.001), poorly differentiated tumors (P=0.009) and more advanced TNM stage (P