Different administration strategies with paclitaxel induce distinct phenotypes of multidrug resistance in breast cancer cells.
Different administration strategies with paclitaxel induce distinct phenotypes of multidrug resistance in breast cancer cells.
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DOI：
10.1016/j.canlet.2013.02.059
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发表时间：
2013-07-28
期刊：
影响因子：
9.7
通讯作者：
Fan, Weimin
中科院分区：
文献类型：
--
作者：
Jiang, Donghai;Sui, Meihua;Zhong, Wangyan;Huang, Yuan;Fan, Weimin
临床上采用剂量密集和剂量递增化疗。通过近似模拟紫杉醇的剂量密集和剂量递增给药方案，成功地从药物敏感的乳腺癌细胞系BCap 37中分离出两株新的多药耐药（MDR）细胞系Bads-200和Bats-72。与Bads-200不同，Bats-72表现出稳定的MDR，并显著增强了迁移和侵袭特性，表明它们代表了两种不同的MDR表型。我们的研究结果表明，不同的MDR表型可以通过改变同一种药物的给药策略来诱导。紫杉醇按常规剂量递增给药可诱导肿瘤细胞复发，并具有稳定的MDR和增加的转移能力。
Both dose-dense and dose-escalation chemotherapy are administered in clinic. By approximately imitating the schedules of dose-dense and dose-escalation administration with paclitaxel, two novel multidrug resistant (MDR) cell lines Bads-200 and Bats-72 were successfully developed from drug-sensitive breast cancer cell line BCap37, respectively. Different from Bads-200, Bats-72 exhibited stable MDR and significantly enhanced migratory and invasive properties, indicating that they represented two different MDR phenotypes. Our results showed that distinct phenotypes of MDR could be induced by altered administration strategies with a same drug. Administrating paclitaxel in conventional dose-escalation schedule might induce recrudescent tumor cells with stable MDR and increased metastatic capacity.
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影响因子：
45.3
作者：
Perez, EA;Vogel, CL;Patel, R
通讯作者：
Patel, R
影响因子：
11.2
作者：
Sui, Meihua;Huang, Yi;Fan, Weimin
通讯作者：
Fan, Weimin
癌细胞适应化学疗法。
影响因子：
3.8
作者：
Di Nicolantonio, F;Mercer, SJ;Knight, LA;Gabriel, FG;Whitehouse, PA;Sharma, S;Fernando, A;Glaysher, S;Di Palma, S;Johnson, P;Somers, SS;Toh, S;Higgins, B;Lamont, A;Gulliford, T;Hurren, J;Yiangou, C;Cree, IA
通讯作者：
Cree, IA
DOI：
10.1074/jbc.m110.200675
发表时间：
2011-10-28
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Achuthan S;Santhoshkumar TR;Prabhakar J;Nair SA;Pillai MR
通讯作者：
Pillai MR
DOI：
10.1080/10245330310001639009
发表时间：
2004-02-01
期刊：
Hematology (Amsterdam, Netherlands)
影响因子：
--
作者：
Grossi, Alberto;Biscardi, Monica
通讯作者：
Biscardi, Monica