3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles.
3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles.
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DOI：
10.1016/j.celrep.2023.112068
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发表时间：
2023-04-25
期刊：
影响因子：
8.8
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中科院分区：
文献类型：
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The spatiotemporal control of gene expression is dependent on the activity of cis-acting regulatory sequences, called enhancers, which regulate target genes over variable genomic distances and -often- by skipping intermediate promoters, suggesting mechanisms that control enhancer-promoter communication. Recent genomics and imaging technologies have revealed highly complex enhancer-promoter interaction networks, while advanced functional studies have started interrogating the forces behind the physical and functional communication among multiple enhancers and promoters. In this review, we first summarize our current understanding of the factors involved in enhancer-promoter communication, with a particular focus on recent papers that have revealed new layers of complexities to old questions. In the second part of the review, we focus on a subset of highly connected enhancer-promoter “hubs” and discuss their potential functions in signal integration and gene regulation as well as the putative factors that might determine their dynamics and assembly.
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DOI：
10.1126/science.abg3074
发表时间：
2021-04-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Abdella R;Talyzina A;Chen S;Inouye CJ;Tjian R;He Y
通讯作者：
He Y
影响因子：
16.6
作者：
Crump NT;Ballabio E;Godfrey L;Thorne R;Repapi E;Kerry J;Tapia M;Hua P;Lagerholm C;Filippakopoulos P;Davies JOJ;Milne TA
通讯作者：
Milne TA
影响因子：
64.5
作者：
Bauer BW;Davidson IF;Canena D;Wutz G;Tang W;Litos G;Horn S;Hinterdorfer P;Peters JM
通讯作者：
Peters JM
影响因子：
16
作者：
Chong, Shasha;Graham, Thomas G. W.;Tjian, Robert
通讯作者：
Tjian, Robert
影响因子：
7
作者：
Beagan JA;Duong MT;Titus KR;Zhou L;Cao Z;Ma J;Lachanski CV;Gillis DR;Phillips-Cremins JE
通讯作者：
Phillips-Cremins JE