Disordered connectivity associated with memory deficits in children with autism spectrum disorders
Disordered connectivity associated with memory deficits in children with autism spectrum disorders
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DOI：
10.1016/j.rasd.2010.04.005
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发表时间：
2011-01-01
影响因子：
2.5
通讯作者：
To, Cho Yee
中科院分区：
文献类型：
--
作者：
Chan, Agnes S.;Han, Yvonne M. Y.;To, Cho Yee
本研究探讨了ASD儿童的记忆表现和皮层连接，并调查这些儿童表现出的记忆缺陷是否与皮层连接有关。21名ASD儿童和21名正常发育（NC）儿童，年龄5-14岁，参加了这项研究。每个孩子都进行了神经心理学测试，包括非语言智力测试（TONI-III），数字广度测试（DS），Rey-Osterrieth复杂图形测试（Rey-O）和香港列表学习测试（HKLLT）;以及在执行视觉编码物体识别（OR）任务时的EEG记录会话。对ASD儿童和正常儿童的6项神经心理学测试和6项脑电相干性测试进行了比较。结果表明，ASD儿童在DS和Rey-O中与正常儿童的水平相当，但在HKLLT和OR中显着较差。他们还表现出显著升高的长程相干性在额-后连接涉及左半球（左前-左后;左前-右后）。Pearson相关分析显示前后脑电相干性与记忆成绩呈显著负相关。(C)2011爱思唯尔有限公司保留所有权利。
The present study examined the memory performance and cortical connectivity of children with ASD, and investigated whether the memory deficits exhibited by these children were associated with the cortical connectivity. Twenty-one children with ASD and 21 children with normal development (NC), aged 5-14 years, participated in the study. Each child was administered a neuropsychological battery that included the Test of Nonverbal Intelligence (TONI-Ill), Digit Span test (DS), Rey-Osterrieth Complex Figure Test (Rey-O), and Hong Kong List Learning Test (HKLLT); and an EEG recording session when performing the visual encoding Object Recognition (OR) task. Six neuropsychological measures from the test battery and six EEG coherence measures in the theta band were compared between the children with ASD and normal children. Results indicated that children with ASD performed at comparable levels with normal children in the DS and Rey-O, but were significantly poorer in HKLLT and OR. They also exhibited significantly elevated long-range coherences in the fronto-posterior connections involving the left hemisphere (left anterior-left posterior; left anterior-right posterior). Pearson correlation showed significant negative associations between the anterior-posterior EEG coherences and memory performance. (C) 2011 Elsevier Ltd. All rights reserved.