A cohort study of indoor nitrogen dioxide and house dust mite exposure in asthmatic children
A cohort study of indoor nitrogen dioxide and house dust mite exposure in asthmatic children
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DOI：
10.1097/01.jom.0000215802.43229.62
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发表时间：
2006-05-01
影响因子：
3.2
通讯作者：
Hiller, Janet E.
中科院分区：
文献类型：
--
作者：
Nitschke, Monika;Pilotto, Louis S.;Hiller, Janet E.
本研究的目的是探讨儿童哮喘症状与室内二氧化氮（NO2）和屋尘螨过敏原（HDM）的剂量反应关系。方法：来自澳大利亚阿德莱德18所小学的哮喘儿童，每天记录症状日记超过12周。2000年冬季，对家庭和教室的NO2水平进行了反复测量。HDM水平从床获得。在研究期开始和结束时进行肺功能检查。结果：收集了174名儿童的暴露和呼吸结果数据。对于学校暴露，白天NO2增加10 ppb导致呼吸困难的估计相对症状率（RR）为1.09 a 10 ppb（95%置信区间[CI] = 1.03-1.15），1.11夜（95% CI = 1.05-1.18），1.12夜胸闷（95% CI = 1.07-1.17）。厨房NO2暴露也发现了显着的症状率增加。这得到厨房暴露的1秒用力呼气量预测百分比与NO2（-0.39%; 95%CI 0.76至-0.02）之间的负剂量反应关系的支持。在致敏儿童的夜间喘息中，HDM暴露的临界点为10 μ g/g，（RR = 3.62，95%CI = 1.49-8.77）、白天咳嗽（RR = 1.64，95%CI = 1.14-2.36）和白天哮喘发作（PLR = 1.95，95%CI = 1.06-3.60）。结论：这项研究基于室内NO2和HDM的剂量反应研究，建立了儿童哮喘症状加重的可靠风险估计。
The purpose of this study was to investigate dose-response relationships between asthma symptoms and indoor nitrogen dioxide (NO2) and house dust mite allergen (HDM) in children. Methods: Asthmatic children from 18 primary schools in Adelaide, Australia, kept a daily symptoms diary over 12 weeks. Home and classroom NO2 levels were measured repeatedly in winter 2000. HDM levels were obtained from beds. Lung function tests were Performed at the beginning and at the end of the study period. Results: Data on exposure and respiratory outcomes were gathered for 174 children. For school exposure, the estimated relative symptom rate (RR) for a 10-ppb increase in NO2 for difficulty breathing during the day was 1.09 a 10-ppb (95% confidence interval [CI] = 1.03-1.15), at night 1.11 (95% CI = 1.05-1.18), and for chest tightness at night 1.12 (95 % CI = 1.07-1.17). Significant symptom rate increases were also found for kitchen NO2 exposure. This was supported by a negative dose-response relationship between Percentage Predicted forced expiratory volume in I second and NO2 (-0.39%; 95 % CI 0.76 to -0.02) for kitchen exposure. Significant threshold effects using a 10-mu g/g cutoff point for HDM exposure were established in the sensitized children for nighttime wheeze (RR = 3.62, 95 % CI = 1.49-8.77), daytime cough (RR = 1.64, 95 % CI = 1.14-2.36), and daytime asthma attack (PLR = 1.95, 95% CI = 1.06-3.60). Conclusion: This stud), has established reliable risk estimates for exacerbations Of asthma symptoms in children based on dose-response investigations of indoor NO2 and HDM.