Associations between indoor light pollution and unhealthy outcomes in 2,947 adults: cross-sectional analysis in the HEIJO-KYO cohort
Associations between indoor light pollution and unhealthy outcomes in 2,947 adults: cross-sectional analysis in the HEIJO-KYO cohort
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室内光污染与 2,947 名成年人的不健康结果之间的关联：HEIJO-KYO 队列的横断面分析
DOI：
10.1016/j.envres.2022.114350
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Saeki K.
中科院分区：
文献类型：
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作者：
Obayashi K;Tai Y;Yamagami Y;Saeki K.
在现代，夜间使用人造光是常见的和必要的。尽管据报道夜间光暴露（LAN）是几种疾病的危险因素，但对室内LAN水平的流行病学研究仍然有限。因此，本研究的目的是测量卧室局域网的水平，使用光度计在一个更大的样本比以前的研究，并评估与综合健康结果的关联。在3012名参与者中，2947人（平均年龄69.3岁;女性，60.6%）完成了卧室LAN强度测量。中位卧室LAN强度为1.0 lux（四分位距，0.2-4.0 lux）。在调整潜在混杂因素的多变量分析中，卧室LAN强度最高的四分位组的体重、体重指数、腹围和低密度脂蛋白胆固醇显著高于最低的四分位组。与LAN强度中位数<10 lux的组相比，LAN强度中位数≥ 10 lux的组的白色血细胞计数显著更高，高密度脂蛋白胆固醇水平显著更低。此外，中位LAN强度≥3和≥10 lux的组的睡眠障碍和抑郁症状的比值比分别显著高于<3和<10 lux的组。因此，本研究提供了卧室LAN水平的真实数据，作为大样本室内光污染的标志，并表明较高的卧室LAN水平与肥胖，血脂异常，全身炎症，睡眠障碍和抑郁症状的参数显著相关。
Nighttime use of artificial light is usual and essential in these modern times. Although light exposure at night (LAN) is reportedly a risk factor of several diseases, epidemiological studies on indoor LAN levels are still limited. Hence, the present study aimed to measure bedroom LAN levels by using light meters in a larger sample than in previous studies, and to evaluate the associations with comprehensive health outcomes. Out of 3012 participants, 2947 (mean age, 69.3 years; female, 60.6%) completed the bedroom LAN intensity measurement. The median bedroom LAN intensity was 1.0 lux (interquartile range, 0.2–4.0 lux). In a multivariable analysis adjusted for potential confounding factors, the highest quartile group of bedroom LAN intensity had significantly higher body weight, body mass index, abdominal circumference, and low-density lipoprotein cholesterol than the lowest quartile group. The group with a median LAN intensity ≥10 lux had significantly higher white blood cell counts and had significantly lower high-density lipoprotein cholesterol levels than the group with a median LAN intensity <10 lux. In addition, the groups with median LAN intensities ≥3 and ≥10 lux had significantly higher odds ratios for sleep disturbances and depressive symptoms than the group with <3 and <10 lux, respectively. Therefore, the present study provided real-world data on bedroom LAN levels as a marker for indoor light pollution in a large sample and suggested that higher bedroom LAN levels are significantly associated with parameters of obesity, dyslipidemia, systemic inflammation, sleep disturbances, and depressive symptoms.