CIGARETTE-SMOKE CONTAINS ANTICOAGULANTS AGAINST FIBRIN AGGREGATION AND FACTOR-XIIIA IN PLASMA
CIGARETTE-SMOKE CONTAINS ANTICOAGULANTS AGAINST FIBRIN AGGREGATION AND FACTOR-XIIIA IN PLASMA
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DOI：
10.1126/science.6124042
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
CHUNG, SI
中科院分区：
文献类型：
--
作者：
GALANAKIS, DK;LAURENT, P;CHUNG, SI
香烟烟雾中的气相水溶性成分导致延迟纤维蛋白自组装，并通过灭活因子XIIIa（血浆转氨酶）阻止纤维蛋白交联。烟雾的这些抗凝特性在血浆中是可证实的，表明它们在吸烟的病理生理学中发挥了作用。
Gas-phase, water-soluble components of cigarette smoke caused delayed fibrin self-assembly and prevented fibrin cross-linking by inactivation of factor XIIIa (plasma transglutaminase). These anticoagulant properties of smoke were demonstrable in plasma, suggesting they played a role in the pathophysiology of smoking.