Elevated level of serum osteopontin in school-age children with asthma
Elevated level of serum osteopontin in school-age children with asthma
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DOI：
10.1016/j.aller.2013.01.009
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发表时间：
2014-07-01
影响因子：
1.8
通讯作者：
Namuslu, M.
中科院分区：
文献类型：
--
作者：
Akelma, A. Z.;Cizmeci, M. N.;Namuslu, M.
背景资料：骨桥蛋白（OPN）在儿童哮喘发病中的作用尚未阐明。目的：探讨学龄前和学龄期儿童过敏性炎症是否会引起OPN水平的变化。在研究人群中研究了OPN水平及其与临床和实验室参数的相关性。哮喘组根据年龄分为两组，5岁（n=28），分别标记为哮喘组1和哮喘组2。结果：哮喘组血清OPN水平显著高于对照组（p=0.004）。哮喘组1和对照组的OPN水平相似，而哮喘组2的OPN水平较高（分别为p>0.025，p=0.001）。在>5岁哮喘组中，变应性鼻炎组（n=15）OPN水平高于非变应性鼻炎组（n=13）（p=0.021）。在这项研究中，我们发现在Th2介导的炎症中起作用的OPN也可能在儿童哮喘中起作用。学龄前哮喘儿童的OPN水平没有增加，这可能是由于该组儿童存在短暂的喘息。(C)2012年SEICAP。出版社：Elsevier Espana，S.L. All rights reserved.
Background: The role of osteopontin (OPN) has not been elucidated in childhood asthma.Objective: Our purpose was to investigate whether OPN levels change due to allergic inflammation in pre-school and school-age children.Methods: In this prospective, cross-sectional study, 42 healthy children and a total of 51 children with asthma were recruited. OPN levels and its association with clinical and laboratory parameters were investigated in the study population. The asthma group were divided into two groups with respect to age, 5-years (n=28), and labelled Asthma Group 1 and Asthma Group 2, respectively. OPN levels were compared between subgroups.Results: Serum OPN levels were significantly higher in the asthma group when compared to the control group (p=0.004). OPN levels were similar in Asthma Group 1 and control groups, whereas it was found to be higher in Asthma Group 2 (p>0.025, p=0.001, respectively). In the >5-years age asthmatic group, OPN levels of the patients with allergic rhinitis (n=15) were higher than those of the patients (n=13) without allergic rhinitis (p=0.021).Conclusion: The study underscores the relationship between childhood asthma and OPN as the first study in the literature. In this study we found that OPN, which plays a role in Th2 mediated inflammation, may also play a role in childhood asthma. The fact that OPN levels do not increase in preschool-age children with asthma might be due to the transient wheezing in this group. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.