FRONTAL BRAIN ASYMMETRY AND IMMUNE FUNCTION
FRONTAL BRAIN ASYMMETRY AND IMMUNE FUNCTION
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DOI：
10.1037/0735-7044.105.6.860
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发表时间：
1991-12-01
影响因子：
1.9
通讯作者：
ERSHLER, WB
中科院分区：
文献类型：
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作者：
KANG, DH;DAVIDSON, RJ;ERSHLER, WB
通过评估20名健康女性的免疫反应来评估大脑活动和免疫系统之间的关系，这些女性在额叶皮层激活的不对称性方面表现出极大的差异。 一组显示极端和稳定的左额叶激活;另一组显示极端和稳定的右额叶激活。 正如预测的那样，与左额叶激活的个体相比，右额叶激活的女性的自然杀伤细胞活性水平显著降低（效应细胞：靶细胞比例为33：1和11：1）。 这种差异并没有延伸到其他两个免疫措施，淋巴细胞增殖和T细胞亚群。 然而，在右额叶组中观察到较高的M类免疫球蛋白水平。 在这项研究中，免疫模式不能用血浆皮质醇水平、焦虑和抑郁相关的精神病学或近期健康史来解释。 这些发现支持了这一假设，即额叶脑不对称性和某些免疫反应之间存在特定关联。
The relation between brain activity and the immune system was evaluated by assessing immune responses in 20 healthy women who manifested extreme differences in the asymmetry of frontal cortex activation. One group showed extreme and stable left frontal activation; the other group showed extreme and stable right frontal activation. As predicted, women with extreme right frontal activation had significantly lower levels of natural killer cell activity (at effector:target cell ratios of 33:1 and 11:1) than did left frontally activated individuals. This difference did not extend to two other immune measures, lymphocyte proliferation and T-cell subsets. However, higher immunoglobulin levels of the M class were observed in the right frontal group. In this study, the immune patterns could not be accounted for by plasma cortisol levels, anxiety- and depression-related symptomatology, or recent health histories. These findings support the hypothesis that there is a specific association between frontal brain asymmetry and certain immune responses.