Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study.
Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study.
复制标题
DOI：
10.1161/circimaging.110.958884
复制
发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Murabito JM
中科院分区：
文献类型：
--
作者：
Fox CS;Massaro JM;Schlett CL;Lehman SJ;Meigs JB;O'Donnell CJ;Hoffmann U;Murabito JM
中心性肥胖与外周动脉疾病(PAD)相关，提示异位脂肪堆积可能与主动脉和下肢动脉的局限性疾病有关。我们假设，主动脉周围脂肪含量较多的人更有可能患有临床外周动脉疾病(PAD)和低踝臂指数(ABI)。我们使用一种新的容量定量方法对来自Framingham心脏研究后代队列(平均年龄65.9岁，女性占54%)的1205名个体的胸主动脉周围的主动脉周围脂肪进行了量化；还测量了内脏腹部脂肪(VAT)。临床PAD被定义为间歇性跛行的病史，ABI被分为低ABI0.9或下肢血运重建与正常的≤；0.9至1.4。建立回归模型以检验腹主动脉周围脂肪与间歇性跛行或低ABI之间的关系(n=66名参与者)。在多变量Logistic回归分析中，主动脉周围脂肪每增加1个标准差，合并终点的优势比(OR)为1.52(p=0.004)；在对体重指数(OR1.69，p=0.002)或内脏腹脂(OR1.67，p=0.009)进行额外调整后，这些结果得到加强，而与增值税无关(p=0.16)。同样，根据BMI或腰围的标准差增加，在计入增值税后没有观察到相关性(p=0.35[BMI]；p=0.49[腰围])。腹主动脉周围脂肪与低ABI和间歇性跛行有关。
Central obesity is associated with peripheral arterial disease (PAD), suggesting that ectopic fat depots may be associated with localized diseases of the aorta and lower extremity arteries. We hypothesized that individuals with greater amounts of peri-aortic fat are more likely to have clinical peripheral arterial disease (PAD) and a low ankle-brachial index (ABI). We quantified peri-aortic fat surrounding the thoracic aorta using a novel volumetric quantitative approach in 1205 individuals from the Framingham Heart Study Offspring cohort (mean age 65.9 years, 54% women); visceral abdominal fat (VAT) was also measured. Clinical PAD was defined as a history of intermittent claudication and ABI was dichotomized as low ABI≤0.9 or lower extremity revascularization vs normal ABI >0.9 to < 1.4. Regression models were created to examine the association between peri-aortic fat and intermittent claudication or low ABI (n=66 participants). In multivariable logistic regression, per 1 standard deviation increase in peri-aortic fat, the odds ratio (OR) for the combined end-point was 1.52 (p-value=0.004); these results were strengthened with additional adjustment for BMI (OR 1.69, p=0.002) or visceral abdominal fat (OR 1.67, p=0.009) whereas no association was observed for VAT (p=0.16). Similarly, per standard deviation increase in BMI or waist circumference, no association was observed after accounting for VAT (p=0.35 [BMI]; p=0.49 [waist circumference]). Peri-aortic fat is associated with low ABI and intermittent claudication.