In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice
In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice
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DOI：
10.1016/s0006-8993(00)02615-9
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发表时间：
2000-09-08
期刊：
影响因子：
2.9
通讯作者：
Henriksen, S
中科院分区：
文献类型：
--
作者：
Giacchino, J;Criado, JR;Henriksen, S
阿尔茨海默病（AD）以进行性神经变性和认知障碍为特征。我们检查了年轻和老年PDAPP转基因小鼠和非转基因幼鼠的海马神经传递的体内变化。我们现在报道，PDAPP小鼠海马回路的体内异常神经传递先于β沉积和神经变性。这些体内数据提供了第一个证据，证明海马神经元回路功能障碍可能与年龄相关的细胞外β斑块沉积无关。(C) 2000 Elsevier Science B.V.版权所有
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and cognitive impairment. We examined in vivo alterations in hippocampal neurotransmission in both young and aged PDAPP transgenic mice and nontransgenic littermates. We now report that in vivo abnormal neurotransmission in hippocampal circuits of PDAPP mice precedes beta deposition and neurodegeneration. These in vivo data provide the first evidence that dysfunction in hippocampal neuronal circuits may not be correlated with age-related extracellular beta plaque deposition. (C) 2000 Elsevier Science B.V. All rights reserved.