Recent trends in the incidence of salivary gland cancer.
Recent trends in the incidence of salivary gland cancer.
复制标题
唾液腺癌发病率的最新趋势。
DOI：
10.1093/ije/20.3.628
复制
发表时间：
1991
影响因子：
7.7
通讯作者：
Brown,SR
中科院分区：
文献类型：
--
作者：
Horn-Ross,PL;West,DW;Brown,SR
从1985年开始，在旧金山-奥克兰大都会统计区，仅在男性中，唾液腺癌发病率突然持续增加了一倍。对登记数据进行了审查，以确定这种增加的性质及其与艾滋病流行的可能联系。通过比较新近诊断病例（1985-1988）与基于人口增长和早期诊断患者的年龄特异性发病率的预期（1973-1984）的分布来评估患者特征的变化。根据观察到的模式，这些肿瘤在时间上的增加不太可能是艾滋病流行的直接结果，也不可能仅仅是既定风险因素流行程度发生变化的结果。这种增加主要出现在诊断时年龄超过75岁的男性中（O/E = 2.3, p = 0.02），并且在患有和未患过癌症的男性中也观察到（O/E = 2.7, p = 0.02和O/E = 1.5, p = 0.06）。先前癌症的放疗与发病率增加无关。军事暴露是通过检查出生队列来粗略估计的。然而，队列数据不支持军事暴露的假设。
Beginning in 1985, a sudden and sustained doubling of salivary gland cancer incidence, among men only, is observed in the San Francisco-Oakland Metropolitan Statistical Area. Registry data are examined to determine the nature of this increase and its possible association with the AIDS epidemic. Changes in patient characteristics are assessed by comparing their distribution among recently diagnosed cases (1985–1988) to an expectation based on population growth and the age-specific incidence among patients diagnosed earlier (1973–1984). Based on the observed patterns, it is unlikely that the temporal increase in these tumours is a direct result of the AIDS epidemic or solely the result of a shift in the prevalence of established risk factors. The increase is predominantly seen in men over the age of 75 at diagnosis (O/E = 2.3, p = 0.02) and is observed among both those with and without a prior cancer (O/E = 2.7, p = 0.02 and O/E = 1.5, p = 0.06, respectively). Radiation for the prior cancer was not associated with increased occurrence. Military exposure is crudely approximated by examining birth cohorts. However, the cohort data do not support a hypothesis of military exposure.