Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.
Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.
复制标题
DOI：
10.1038/srep35690
复制
发表时间：
2016-10-19
影响因子：
4.6
通讯作者：
Araki E
中科院分区：
文献类型：
--
作者：
Kondo T;Goto R;Ono K;Kitano S;Suico MA;Sato M;Igata M;Kawashima J;Motoshima H;Matsumura T;Kai H;Araki E
热休克反应 (HSR) 的激活可改善 2 型糖尿病中累积的内脏肥胖和代谢异常。旨在确定 2 型糖尿病中轻度电刺激 (MES) 结合热休克 (HS) 激活 HSR 的最佳干预策略。这项研究是在日本进行的一项前瞻性、频率递增、随机、开放标签的三臂试验。总共 60 名肥胖 2 型糖尿病患者被随机分为三组，每周接受 2 次、4 次或 7 次治疗，持续 12 周。没有发现不良事件。与基线相比，MES + HS治疗（当所有三组合并时）显着改善内脏肥胖、血糖控制、胰岛素抵抗、全身炎症、肾功能、肝脂肪变性和血脂状况。每周治疗 4 次 (-0.36%) 或每周 7 次 (-0.65%) 的患者 HbA1c 降低幅度显着大于每周治疗 2 次的患者 (-0.10%)。当调整为每周两次组时，每周七次组的相对 HbA1c 水平显着下降（-0.55%。p = 0.001）。这项研究提供了 MES + HS 对治疗肥胖 2 型糖尿病患者的积极影响。
Activation of heat shock response (HSR) improves accumulated visceral adiposity and metabolic abnormalities in type 2 diabetes. To identify the optimal intervention strategy of the activation of the HSR provided by mild electrical stimulation (MES) with heat shock (HS) in type 2 diabetes. This study was a prospective, frequency-escalating, randomized, open-label, triple-arm trial in Japan. A total of 60 obese type 2 diabetes patients were randomized into three groups receiving two, four, or seven treatments per week for 12 weeks. No adverse events were identified. MES + HS treatment (when all three groups were combined), significantly improved visceral adiposity, glycemic control, insulin resistance, systemic inflammation, renal function, hepatic steatosis and lipid profile compared to baseline. The reduction in HbA1c was significantly greater among those treated four times per week (−0.36%) or seven times per week (−0.65%) than among those treated two times per week (−0.10%). The relative HbA1c levels in seven times per week group was significantly decreased when adjusted by two times per week group (−0.55%. p = 0.001). This research provides the positive impact of MES + HS to treat obese patients with type 2 diabetes mellitus.
登录
查看更多内容
影响因子：
11.1
作者：
Kondo, Tatsuya;Ono, Kaoru;Kitano, Sayaka;Matsuyama, Rina;Goto, Rieko;Suico, Mary Ann;Kawasaki, Shuji;Igata, Motoyuki;Kawashima, Junji;Motoshima, Hiroyuki;Matsumura, Takeshi;Kai, Hirofumi;Araki, Eiichi
通讯作者：
Araki, Eiichi
影响因子：
7.7
作者：
Kondo T;Sasaki K;Matsuyama R;Morino-Koga S;Adachi H;Suico MA;Kawashima J;Motoshima H;Furukawa N;Kai H;Araki E
通讯作者：
Araki E
影响因子：
3.7
作者：
Matsuyama S;Moriuchi M;Suico MA;Yano S;Morino-Koga S;Shuto T;Yamanaka K;Kondo T;Araki E;Kai H
通讯作者：
Kai H
影响因子：
7.4
作者：
Jarmuszkiewicz, Wieslawa;Woyda-Ploszczyca, Andrzej;Zoladz, Jerzy A.
通讯作者：
Zoladz, Jerzy A.
影响因子：
2.1
作者：
Hooper, Philip L.
通讯作者：
Hooper, Philip L.