The RAD5-dependent postreplication repair pathway is important to suppress gross chromosomal rearrangements.
The RAD5-dependent postreplication repair pathway is important to suppress gross chromosomal rearrangements.
复制标题
RAD5 依赖性复制后修复途径对于抑制总体染色体重排非常重要。
DOI：
10.1093/jncimonographs/lgn019
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Smith,Stephanie
中科院分区：
文献类型：
--
作者：
Myung,Kyungjae;Smith,Stephanie
Genome instability is characteristic of cancer cells. Although it frequently occurs during carcinogenesis, the mechanism underlying genome instability is not clearly understood. Recent extensive genetic analyses from different organisms have begun to reveal mechanisms for the suppression of genome instability in general DNA metabolisms including DNA replication, recombination, DNA repair, and signal transduction. One DNA repair pathway called postreplication repair (also known as DNA damage bypass) has been highlighted for its role in genome stability. Central to DNA damage bypass, proliferating cell nuclear antigen (PCNA) directs different pathways through its mono- or polyubiquitination and sumoylation. In this review, we will discuss template switching dictated by the PCNA polyubiquitination and its roles in the suppression of genome instabilities.
