Distribution of Specific High‐Affinity Binding Sites for [3H]Imipramine in Human Brain
Distribution of Specific High‐Affinity Binding Sites for [3H]Imipramine in Human Brain
复制标题
人脑中[3H]丙咪嗪特异性高亲和力结合位点的分布
DOI：
10.1111/j.1471-4159.1981.tb00450.x
复制
发表时间：
1981
影响因子：
4.7
通讯作者：
Y. Agid
中科院分区：
文献类型：
--
作者：
S. Z. Langer;F. Javoy‐Agid;R. Raisman;M. Briley;Y. Agid
翻译后摘要：[3H]丙咪嗪结合高亲和力的膜从不同地区的人脑。下丘脑和黑质中的结合位点密度最高，白色物质和小脑中的结合位点密度最低。在大鼠脑中发现，三环类抗抑郁药是[3H]丙咪嗪结合的有效抑制剂。然而，非典型的抗抑郁药在抑制特异性结合方面要弱得多。[3H]丙咪嗪结合位点在人类皮层显然是相同的网站已经在大鼠大脑和人类血小板中描述。
Abstract: [3H]Imipramine binds with high affinity to membranes from different regions of the human brain. The highest density of binding sites was observed in the hypothalamus and substantia nigra and the lowest density in the white matter and cerebellum. As found in rat brain, tricyclic antidepressant drugs are potent inhibitors of [3H]imipramine binding. Atypical antidepressants are, however, much weaker at inhibiting the specific binding. The [3H]imipramine binding site in human cortex is apparently identical to the site already described in the rat brain and in human platelets.